Designer diamonds could one day help build a quantum internet

A new kind of artificial diamond is a cut above the rest for quantum memory.

Unlike other synthetic diamonds, which could either store quantum information for a long time or transmit it clearly, the new diamond can do both. This designer crystal, described in the July 6 Science, could be a key building block in a quantum internet. Such a futuristic communications network would allow people to send supersecure messages and connect quantum computers around the world (SN: 10/15/16, p. 13).
Synthetic diamond can serve as quantum storage thanks to a type of flaw in its carbon lattice, where two neighboring carbon atoms are replaced with one noncarbon atom and an empty space (SN: 4/5/08, p. 216). This pairing exhibits a quantum property known as spin, which can be in an “up” state, a “down” state or both at once. Each of those states reflects a bit of quantum data, or qubit, that may be 1, 0 or both at once. A diamond transmits qubits by encoding them in light particles, or photons, that travel through fiber-optic cables.

Qubit-storing diamond defects are typically made with nitrogen atoms, which can store quantum data for milliseconds — a relatively long time in the quantum realm (SN: 4/23/11, p. 14). But nitrogen defects can’t communicate that data clearly. They emit light particles at a broad range of frequencies, which muddles the quantum information written into the photons.

Defects made with silicon atoms emit light more precisely, but until now haven’t been able to store qubits for longer than several nanoseconds due to their electrical interactions with nearby particles, explains Nathalie de Leon, an electrical engineer at Princeton University.

De Leon and colleagues got around this problem by forging silicon defects in a diamond infused with boron. This extra chemical ingredient shielded the delicate silicon defects from electrical interactions with nearby particles, extending the defects’ quantum memory. The boron-infused crystal nearly rivaled the long-term quantum memory of nitrogen defects, storing qubits for about a millisecond. And it gave a clean photon readout, emitting about 90 percent of its photons at the exact same frequency — compared to just 3 percent of photons spat out by nitrogen defects.
Tweaking the environment of the silicon defects was “an extremely creative way” to help keep a better grip on qubits, says Evelyn Hu, an applied physicist and electrical engineer at Harvard University not involved in the work.

This new artificial diamond could be used to construct devices called quantum repeaters for long-distance quantum communications, says David Awschalom, a physicist and quantum engineer at the University of Chicago who wasn’t involved in the work. Qubit-carrying photons can travel only up to about 100 kilometers through optical fiber before their signal gets scrambled (SN: 9/30/17, p. 8). Quantum repeaters that catch, store and re-emit photons could serve as stepping stones between fiber-optic cables to extend the reach of future networks.

Why humans, and Big Macs, depend on bees

When you hear the word bee, the image that pops to mind is probably a honeybee. Maybe a bumblebee. But for conservation biologist Thor Hanson, author of the new book Buzz, the world is abuzz with thousands of kinds of bees, each as beautiful and intriguing as the flowers on which they land.

Speaking from his “raccoon shack” on San Juan Island in Washington — a backyard shed converted to an office and bee-watching space, and named for its previous inhabitants — Hanson shares what he’s learned about how bees helped drive human evolution, the amazing birds that lead people to honey, and what a Big Mac would look like without bees. The following conversation has been edited for length and clarity.
SN: This bee book is unusual — it isn’t mainly about honeybees. Why did you write about lesser-known bees?

Hanson: I made a deliberate decision because I thought the celebrity bees, the honeybees, would steal the show. It was high time to turn a stage light onto these 20,000 other species of bees, which have habits that are less familiar but just as fascinating. For example, most people think of hives when they think of bees, but actually most bees are solitary.

SN: You write that this book is an “exploration of how the very nature of bees makes them so utterly necessary.” So let’s cut to the chase: Why are bees necessary?
Hanson: First is the deep connection between bees and flowering plants. They’ve had a partnership from an early stage; each spurs the other in terms of diversity. It’s an incredible role that bees have played in shaping the natural world. They’re also important to our lifestyle, first for their role in the human diet. It’s often said that one of every three bites of food depends on bees.

But there are all these other connections that we don’t think about: Bees have provided light from beeswax candles and sweetness from honey. Early industrial uses of wax included making bronze sculptures with wax molds, batiks in Indonesia and wax tablets to write on.

You can trace our relationship with bees back not hundreds, but hundreds of thousands of years. The role of honey in the human diet goes back into prehistory. That source of sugar may have even helped fuel the expansion of our brain size. It may have helped us become who we are.
SN: One of the most astonishing examples of our relationship with bees has to do with a bird called the honeyguide. Tell me about that.

Hanson: Hunter-gatherers in Africa follow this bird to bees’ nests, and have for generations (SN: 8/20/16, p. 10). The honeyguide is very good at locating a hive. But on its own, it can’t access the nest. So once it locates one, the next thing it does is look for people. It hops around on branches and makes a piercing cry to get attention, then leads a person to the honey. People climb the tree or dig out the nest, and honeyguides feed on the remains.

What’s funny is how long it took biologists to figure out this relationship. The original explanation was that the honeyguide coevolved with the honey badger, which also raids nests for honey. Then a biologist pointed out that badgers are nocturnal, and the birds aren’t. Also, no one has ever seen a honeyguide leading a badger. It makes more sense that the relationship evolved on the savannah with people out looking for honey every day.

SN: One of the book’s most hilariously geeky moments is when you go to McDonald’s and pick apart a Big Mac. Why did you do that?

Hanson: I wanted to look for the significance of bees in an unexpected place. And you don’t think of bees when you go into McDonald’s — you just don’t! I didn’t care how much people stared. I sat there with my tweezers, pulling all the seeds off the bun. I ended up with one pile you could have without bees [meat and bun] and one you couldn’t [including not only the veggies, but also the cheese and special sauce]. We could still eat, but it would be pretty dull.

SN: You’re worried about bees. Why?

Hanson: It’s the four p’s: pesticides, pathogens, parasites and poor nutrition. Poor nutrition is one that people don’t think of. We ship honeybees all over the place, and they get force-fed almond blossoms for three weeks, then they’re packed onto trucks and shipped off to pollinate apples. It’s not a healthy lifestyle, and not a varied diet.

SN: You say that bees are one of the few insects that inspire fondness instead of fear. Why do you think that is?

Hanson: Bees have been with us from the beginning. Our primordial sweet tooth led us to follow these creatures, then we domesticated bees very early on, setting out hives and reusing good sites in baobab trees. I think we have a very deep connection to these creatures.

China just landed the first spacecraft on the moon’s farside

China’s Chang’e-4 lander and rover just became the first spacecraft to land on the farside of the moon.

The lander touched down at 9:26 p.m. Eastern time on January 2, according to an announcement from the China National Space Administration. The spacecraft is part of a series of Chinese space missions named Chang’e (pronounced CHONG-uh) for the Chinese goddess of the moon.

A small rover dubbed Yutu 2, or Jade Rabbit 2, rolled off the craft several hours after landing. The rover will explore the terrain around the 186-kilometer-wide Von Kármán crater located inside the 2,500-kilometer-wide South Pole–Aitken basin. The basin, one of the largest and oldest impact features in the solar system, could contain exposed parts of the moon’s interior that might reveal details of its formation and early history (SN: 11/24/18, p. 14).
Chang’e-4 will measure some of the region’s composition, use ground-penetrating radar to probe just below the surface, and take panoramic images of a landscape that has never been seen from the ground before. It will also make measurements of charged particles and radiation, which could help support future astronaut missions, and test whether plants and insects can grow together on the moon.
Because the moon always shows the same face to Earth, it is impossible to communicate directly with spacecraft on the farside. A relay satellite named Queqiao, or Magpie Bridge, that launched in May 2018 will beam signals between Chang’e-4 and Earth (SN Online: 5/20/18).
The landing marks China’s second lunar landing, and a step towards more ambitious moon missions. The Chinese space agency is planning another mission to collect moon rock samples later in 2019.

The physics of fluids explains how crowds of marathon runners move

Marathoners queuing up for a big race tend to go with the flow, surging toward the start line like a fluid.

Using footage of runners moving in groups toward the start of the Chicago Marathon, researchers developed a theory that treats the crowd like a liquid to explain its movement. The theory correctly predicted the motion of crowds of runners at marathons in two other locations, physicists report in the Jan. 4 Science.

Previous studies have devised rules for how individuals act within a crowd and used that behavior to describe crowd motion (SN: 1/10/15, p. 15). But to understand how wine swirls in a glass, you don’t need to know the behavior of each molecule. So physicists Nicolas Bain and Denis Bartolo of École Normale Supérieure de Lyon in France considered the crowd as a whole.

At the start of a marathon, runners arrange themselves into groups known as corrals, which individually advance to the starting line. Marathon staff members form a line in front of each corral, periodically holding participants back until there’s space to move forward. The researchers filmed this start-and-stop process at four marathons, including the Chicago Marathon in 2016 and 2017. The movements of the staff set off a change in crowd density and speed that traveled through the throng akin to waves produced when water is pushed, the team found. Similar effects occurred at marathons in Paris and Atlanta in 2017.

Marathon crowds are a special type in that everyone travels in the same direction. Eventually, this type of research could lead to new insight into other crowd formations, including those packed more tightly than marathon crowds, with pedestrians literally shoulder to shoulder. Such crowds sometimes result in deadly stampedes, such as the 2015 event at the hajj in Mecca, Saudi Arabia (SN: 4/7/07, p. 213). Better understanding of these crowd dynamics could help prevent similar tragedies.

The science of CBD lags behind its marketing

Treatments for pain and other common health problems often fall short, leading to untold misery and frustration. So it’s not hard to understand the lure of a treatment that promises to be benign, natural and good for just about everything that ails you. Enter cannabidiol, or CBD.

So far, the U.S. Food and Drug Administration has approved only one drug containing the chemical: a treatment for rare and severe forms of epilepsy. But that hasn’t stopped people from trying CBD to relieve arthritis, morning sickness, pain, depression, anxiety, addiction, inflammation and acne. And it hasn’t kept companies from marketing the heck out of CBD-infused anything. It’s the sort of situation that gets us wondering: What’s the science here?
The science is skimpy at best, neuroscience writer Laura Sanders reports in this issue. Clinical trials, some of which included children, were conducted to determine safety and efficacy before the FDA approved the first CBD-based epilepsy drug in 2018. But much less research has been done on CBD with regard to other ailments.

Adding to the intrigue, CBD can be extracted from marijuana, though CBD lacks the capacity to induce a buzzy high like its sister molecule THC. So government restrictions have been tight, and scientists have had a hard time getting access to CBD for studies. That makes it less likely that we’ll get clear answers anytime soon on whether CBD is indeed a panacea, or just another triumph of hype.

The surplus of unknowns hasn’t stopped companies from marketing hundreds of CBD products as treatments, attempting to avoid scrutiny by adding disclaimers that the products “are not intended to diagnose, treat or cure or prevent any disease.” But with such large gaps in the research, people trying these products in the hope of benefit become inadvertent guinea pigs.

The process of science may be frustratingly slow, but it can get the job done. In the last decade, clinical trials on vitamin D, for example, have found that despite much excitement surrounding the “sunshine vitamin,” there’s no definitive evidence of benefits in preventing heart disease or cancer. In our recent cover story “Vitamin D supplements aren’t living up to their hype,” contributing correspondent Laura Beil described the years of effort needed to develop that data (SN: 2/2/19, p. 16).
As journalists, we see a big part of our mission as making sure that people have access to accurate, timely information about medical research, so people can make informed decisions for themselves and their families. That’s especially important when it involves products that people can self-prescribe. These two articles — by skilled journalists who put weeks of effort into reading studies, talking with researchers and investigating the business side — are great examples of how sophisticated and useful consumer science journalism can be. Most people look for health information online, but Googling a term like “CBD oil” serves up a muddle of marketing masquerading as impartial information.

CBD may end up being a worthwhile treatment for some problems beyond epilepsy; it’s too early to know. But while we wait for the evidence, it’s essential to know where the science stands right now.

Treating cystic fibrosis patients before birth could safeguard organs

A drug that treats a rare form of cystic fibrosis may have even better results if given before birth, a study in ferrets suggests.

The drug, known by the generic name ivacaftor, can restore the function of a faulty version of the CFTR protein, called CFTRG551D. The normal CFTR protein controls the flow of charged atoms in cells that make mucus, sweat, saliva, tears and digestive enzymes. People who are missing the CFTR gene and its protein, or have two copies of a damaged version of the gene, develop the lung disease cystic fibrosis, as well as diabetes, digestive problems and male infertility.
Ivacaftor can reduce lung problems in patients with the G551D protein defect, with treatment usually starting when a patient is a year old. But if the results of the new animal study carry over to humans, an even earlier start date could prove more effective in preventing damage to multiple organs.

Researchers used ferret embryos with two copies of the G551D version of the CFTR gene. Giving the drug to mothers while the ferrets were in the womb and then continuing treatment of the babies after birth prevented male infertility, pancreas problems and lung disease in the baby ferrets, called kits, researchers report March 27 in Science Translational Medicine. The drug has to be used continuously to prevent organ damage — when the drug was discontinued, the kits’ pancreases began to fail and lung disease set in.

Cystic fibrosis affects about 30,000 people in the United States and 70,000 worldwide. But only up to 5 percent of patients have the G551D defect.

Other researchers are testing combinations of three drugs, including ivacaftor, aimed at helping the roughly 90 percent of cystic fibrosis patients afflicted by another genetic mutation that causes the CFTR protein to lack an amino acid (SN: 11/24/18, p. 11). Those drug combos, if proven effective, might also work better if administered early, cystic fibrosis researcher Thomas Ferkol of Washington University School of Medicine in St. Louis writes in a commentary published with the study.

How scientists took the first picture of a black hole

Black holes are extremely camera shy. Supermassive black holes, ensconced in the centers of galaxies, make themselves visible by spewing bright jets of charged particles or by flinging away or ripping up nearby stars. Up close, these behemoths are surrounded by glowing accretion disks of infalling material. But because a black hole’s extreme gravity prevents light from escaping, the dark hearts of these cosmic heavy hitters remain entirely invisible.

Luckily, there’s a way to “see” a black hole without peering into the abyss itself. Telescopes can look instead for the silhouette of a black hole’s event horizon — the perimeter inside which nothing can be seen or escape — against its accretion disk. That’s what the Event Horizon Telescope, or EHT, did in April 2017, collecting data that has now yielded the first image of a supermassive black hole, the one inside the galaxy M87.

“There is nothing better than having an image,” says Harvard University astrophysicist Avi Loeb. Though scientists have collected plenty of indirect evidence for black holes over the last half century, “seeing is believing.”

Creating that first-ever portrait of a black hole was tricky, though. Black holes take up a minuscule sliver of sky and, from Earth, appear very faint. The project of imaging M87’s black hole required observatories across the globe working in tandem as one virtual Earth-sized radio dish with sharper vision than any single observatory could achieve on its own.
Putting the ‘solution’ in resolution
Weighing in around 6.5 billion times the mass of our sun, the supermassive black hole inside M87 is no small fry. But viewed from 55 million light-years away on Earth, the black hole is only about 42 microarcseconds across on the sky. That’s smaller than an orange on the moon would appear to someone on Earth. Still, besides the black hole at the center of our own galaxy, Sagittarius A* or Sgr A* — the EHT’s other imaging target — M87’s black hole is the largest black hole silhouette on the sky.
Only a telescope with unprecedented resolution could pick out something so tiny. (For comparison, the Hubble Space Telescope can distinguish objects only about as small as 50,000 microarcseconds.) A telescope’s resolution depends on its diameter: The bigger the dish, the clearer the view — and getting a crisp image of a supermassive black hole would require a planet-sized radio dish.
Even for radio astronomers, who are no strangers to building big dishes (SN Online: 9/29/17), “this seems a little too ambitious,” says Loeb, who was not involved in the black hole imaging project. “The trick is that you don’t cover the entire Earth with an observatory.”
Instead, a technique called very long baseline interferometry combines radio waves seen by many telescopes at once, so that the telescopes effectively work together like one giant dish. The diameter of that virtual dish is equal to the length of the longest distance, or baseline, between two telescopes in the network. For the EHT in 2017, that was the distance from the South Pole to Spain.

Telescopes, assemble!
The EHT was not always the hotshot array that it is today, though. In 2009, a network of just four observatories — in Arizona, California and Hawaii — got the first good look at the base of one of the plasma jets spewing from the center of M87’s black hole (SN: 11/3/12, p. 10). But the small telescope cohort didn’t yet have the magnifying power to reveal the black hole itself.

Over time, the EHT recruited new radio observatories. By 2017, there were eight observing stations in North America, Hawaii, Europe, South America and the South Pole. Among the newcomers was the Atacama Large Millimeter/submillimeter Array, or ALMA, located on a high plateau in northern Chile. With a combined dish area larger than an American football field, ALMA collects far more radio waves than other observatories.

“ALMA changed everything,” says Vincent Fish, an astronomer at MIT’s Haystack Observatory in Westford, Mass. “Anything that you were just barely struggling to detect before, you get really solid detections now.”
More than the sum of their parts
EHT observing campaigns are best run within about 10 days in late March or early April, when the weather at every observatory promises to be the most cooperative. Researchers’ biggest enemy is water in the atmosphere, like rain or snow, which can muddle with the millimeter-wavelength radio waves that the EHT’s telescopes are tuned to.

But planning for weather on several continents can be a logistical headache.

“Every morning, there’s a frenetic set of phone calls and analyses of weather data and telescope readiness, and then we make a go/no-go decision for the night’s observing,” says astronomer Geoffrey Bower of the Academia Sinica Institute of Astronomy and Astrophysics in Hilo, Hawaii. Early in the campaign, researches are picky about conditions. But toward the tail end of the run, they’ll take what they can get.

When the skies are clear enough to observe, researchers steer the telescopes at each EHT observatory toward the vicinity of a supermassive black hole and begin collecting radio waves. Since M87’s black hole and Sgr A* appear on the sky one at a time — each one about to rise just as the other sets — the EHT can switch back and forth between observing its two targets over the course of a single multi-day campaign. All eight observatories can track Sgr A*, but M87 is in the northern sky and beyond the South Pole station’s sight.

On their own, the data from each observing station look like nonsense. But taken together using the very long baseline interferometry technique, these data can reveal a black hole’s appearance.

Here’s how it works. Picture a pair of radio dishes aimed at a single target, in this case the ring-shaped silhouette of a black hole. The radio waves emanating from each bit of that ring must travel slightly different paths to reach each telescope. These radio waves can interfere with each other, sometimes reinforcing one another and sometimes canceling each other out. The interference pattern seen by each telescope depends on how the radio waves from different parts of the ring are interacting when they reach that telescope’s location.
For simple targets, such as individual stars, the radio wave patterns picked up by a single pair of telescopes provide enough information for researchers to work backward and figure out what distribution of light must have produced those data. But for a source with complex structure, like a black hole, there are too many possible solutions for what the image could be. Researchers need more data to work out how a black hole’s radio waves are interacting with each other, offering more clues about what the black hole looks like.

The ideal array has as many baselines of different lengths and orientations as possible. Telescope pairs that are farther apart can see finer details, because there’s a bigger difference between the pathways that radio waves take from the black hole to each telescope. The EHT includes telescope pairs with both north-south and east-west orientations, which change relative to the black hole as Earth rotates.

Pulling it all together
In order to braid together the observations from each observatory, researchers need to record times for their data with exquisite precision. For that, they use hydrogen maser atomic clocks, which lose about one second every 100 million years.

There are a lot of data to time stamp. “In our last experiment, we recorded data at a rate of 64 gigabits per second, which is about 1,000 times [faster than] your home internet connection,” Bower says.

These data are then transferred to MIT Haystack Observatory and the Max Planck Institute for Radio Astronomy in Bonn, Germany, for processing in a special kind of supercomputer called a correlator. But each telescope station amasses hundreds of terabytes of information during a single observing campaign — far too much to send over the internet. So the researchers use the next best option: snail mail. So far, there have been no major shipping mishaps, but Bower admits that mailing the disks is always a little nerve-wracking.

Though most of the EHT data reached Haystack and Max Planck within weeks of the 2017 observing campaign, there were no flights from South Pole until November. “We didn’t get the data back from the South Pole until mid-December,” says Fish, the MIT Haystack astronomer.

Filling in the blanks
Combining the EHT data still isn’t enough to render a vivid picture of a supermassive black hole. If M87’s black hole were a song, then imaging it using only the combined EHT data would be like listening to the piece played on a piano with a bunch of broken keys. The more working keys — or telescope baseline pairs — the easier it is to get the gist of the melody. “Even if you have some broken keys, if you’re playing all the rest of them correctly, you can figure out the tune, and that’s partly because we know what music sounds like,” Fish says. “The reason we can reconstruct images, even though we don’t have 100 percent of the information, is because we know what images look like” in general.
There are mathematical rules about how much randomness any given picture can contain, how bright it should be and how likely it is that neighboring pixels will look similar. Those basic guidelines can inform how software decides which potential images, or data interpretations, make the most sense.

Before the 2017 observing campaign, the EHT researchers held a series of imaging challenges to make sure their computer algorithms weren’t biased toward creating images to match expectations of what black holes should look like. One person would use a secret image to generate faux data of what telescopes would see if they were peering at that source. Then other researchers would try to reconstruct the original image.

“Sometimes the true image was not actually a black hole image,” Fish says, “so if your algorithm was trying to find a black hole shadow … you wouldn’t do well.” The practice runs helped the researchers refine the data processing techniques used to render the M87 image.

Black holes and beyond
So, the black hole inside M87 finally got its closeup. Now what?

The EHT’s black hole observations are expected to help answer questions like how some supermassive black holes, including M87’s, launch such bright plasma jets (SN Online: 3/29/19). Understanding how gas falls into and feeds black holes could also help solve the mystery of how some black holes grew so quickly in the early universe, Loeb says (SN Online: 3/16/18).

The EHT could also be used, Loeb suggests, to find pairs of supermassive black holes orbiting one another — similar to the two stellar mass black holes whose collision created gravitational waves detected in 2015 by the Advanced Laser Interferometer Gravitational-Wave Observatory, or Advanced LIGO (SN: 3/5/16, p. 6). Getting a census of these binaries may help researchers identify targets for the Laser Interferometer Space Antenna, or LISA, which will search from space for gravitational waves kicked up by the movement of objects like black holes (SN Online: 6/20/17).
The EHT doesn’t have many viable targets other than supermassive black holes, says astrophysicist Daniel Marrone, at the University of Arizona in Tucson. There are few other things in the universe that appear as tiny but luminous as the space surrounding a supermassive black hole. “You have to be able to get enough light out of the really tiny patches of sky that we can detect,” Marrone says. “In principle, we could be reading alien license plates or something,” but they’d need to be super bright.

Too bad for alien seekers. Still, even if the EHT is a one-trick pony, spying supermassive black holes is a pretty neat trick.

Ketamine cultivates new nerve cell connections in mice

Ketamine banishes depression by slowly coaxing nerve cells to sprout new connections, a study of mice suggests. The finding, published in the April 12 Science, may help explain how the hallucinogenic anesthetic can ease some people’s severe depression.

The results are timely, coming on the heels of the U.S. Food and Drug Administration’s March 5 approval of a nasal spray containing a form of ketamine called esketamine for hard-to-treat depression (SN Online: 3/21/19). But lots of questions remain about the drug.
“There is still a lot of mystery in terms of how ketamine works in the brain,” says neuroscientist Alex Kwan of Yale University. The new study adds strong evidence that newly created nerve cell connections are involved in ketamine’s antidepressant effects, he says.

While typical antidepressants can take weeks to begin working, ketamine can make people feel better in hours. Scientists led by neuroscientist Conor Liston suspected that ketamine might quickly be remodeling the brain by spurring new nerve cell connections called synapses. “As it turned out, that wasn’t true, not in the way we expected, anyway,” says Liston, of Cornell University.

Newly created synapses aren’t involved in ketamine’s immediate effects on behavior, the researchers found. But the nerve cell connections do appear to help sustain the drug’s antidepressant benefits over the longer term.

To approximate depression in people, researchers studied mice that had been stressed for weeks, either by being restrained daily in mesh tubes, or by receiving injections of the stress hormone corticosterone. These mice began showing signs of despair, such as losing their taste for sweet water and giving up a struggle when dangled by their tails.
Three hours after a dose of ketamine, the mice’s behavior righted, as the researchers expected. But the team found no effects of the drug on nerve cells’ dendritic spines — tiny signal-receiving blebs that help make new neural connections. So the creation of new synapses couldn’t be responsible for ketamine’s immediate effects on behavior, “because the behavior came first,” Liston says.

When the researchers looked over a longer time span, though, they found that these new synapses were key. About 12 hours after ketamine treatment, new dendritic spines began to pop into existence on nerve cells in part of the mice’s prefrontal cortex, the brain area responsible for complex thinking. These dendritic spines seemed to be replacing those lost during the period of stress, often along the same stretch of neuron.

To test if these newly created spines were important for the mice’s improved behavior, the researchers destroyed the spines with a laser a day after the ketamine treatment. That effectively erased ketamine’s effects, and the mice again exhibited behavior resembling depression, including struggling less when held by their tails. (The mice kept their regained sugar preference.)

Research on humans has also suggested that depressed people have diminished synapses, says Ronald S. Duman, a neuroscientist at Yale University not involved in the study. The new work adds more support to those findings by showing that destroying new synapses can block ketamine’s behavioral effects. “That’s a huge contribution and advance,” Duman says.

Ancient humans used the moon as a calendar in the sky

The sun’s rhythm may have set the pace of each day, but when early humans needed a way to keep time beyond a single day and night, they looked to a second light in the sky. The moon was one of humankind’s first timepieces long before the first written language, before the earliest organized cities and well before structured religions. The moon’s face changes nightly and with the regularity of the seasons, making it a reliable marker of time.

“It’s an obvious timepiece,” Anthony Aveni says of the moon. Aveni is a professor emeritus of astronomy and anthropology at Colgate University in Hamilton, N.Y., and a founder of the field of archaeoastronomy. “There is good evidence that [lunar timekeeping] was around as early as 25,000, 30,000, 35,000 years before the present.”

When people began depicting what they saw in the natural world, two common motifs were animals and the night sky. One of the earliest known cave paintings, dated to at least 40,000 years ago in a cave on the island of Borneo, includes a wild bull with horns. European cave art dating to about 37,000 years ago depicts wild cattle too, as well as geometric shapes that some researchers interpret as star patterns and the moon.

For decades, prehistorians and other archaeologists believed that ancient humans were portraying what they saw in the natural world because of an innate creative streak.
The modern idea that Paleolithic people were depicting nature for more than artistic reasons gained traction at the end of the 19th century and was further developed in the early 20th century by Abbé Henri Breuil, a French Catholic priest and archaeologist. He interpreted the stylistic bison and lions in the cave paintings and carvings of southern France as ritual art designed to bring luck to the hunt.

In the 1960s, a journalist–turned–amateur anthropologist proposed even more practical purposes for these drawings and other artifacts: They were created for telling time.

In the early days of the Apollo space missions, the journalist, Alexander Marshack, was writing a book about how the course of human history culminated in the moon shot. He delved into prehistory, trying to understand the earliest concepts of timekeeping and agriculture (SN: 4/14/79, p. 252).

“I had a profound sense of something missing,” Marshack wrote in his 1972 book, The Roots of Civilization. Formal science, including astronomy and math, apparently had begun “suddenly,” he noted. Same with writing, agriculture, art and the calendar. But surely these cognitive leaps took thousands of years of preparation, Marshack reasoned: “How many thousands was the question.”

To find out, he examined ancient bone carvings and wall art from locations including caves in Western Europe and fishing villages of equatorial Africa. He interpreted what was seen by some as simple dots and dashes or depictions of animals and people as sophisticated tools for keeping track of time — via the moon. Today, some experts support his thesis; others remain unconvinced.
It’s easy enough to keep track of the seasons just by paying attention to the environment, of course. Throughout the world, animals like deer and cattle are pregnant through the winter’s dark privation; they give birth when the leaves appear on trees and when grasses grow tall.

Early humans of 30,000 years ago frequently connected the changes in these “phenophases,” the seasonal stages of flora and fauna, with the appearance of certain stars and the phases of the moon, says science historian and astronomer Michael Rappenglück of the Adult Education Center and Observatory in Gilching, Germany. He refers to early cave depictions as “paleo-almanacs” because they combined time-reckoning with information related to the cycles of life.

As Rappenglück puts it, simply noting the spinning of the seasons would not be enough to keep time. For one thing, flora and fauna change from place to place, and even 30,000 years ago, humans were traveling great distances in search of food. They needed something more constant to help them tell time.

“People carefully watched the course of the moon, noting its position over the natural horizon and the change of its phases,” Rappenglück wrote in the 2015 Handbook of Archaeoastronomy and Ethnoastronomy.

In the 1960s, Marshack, the first to argue that Paleolithic people were connecting the moon with time, sifted through dusty cabinets in French museums, retrieving bone and antler pieces that had been worked by humans. Others had interpreted the etchings on these objects as the by-product of point-sharpening, or maybe, as most before Breuil thought, abstract artworks made by idle hands.

But Marshack saw the earliest examples of sky almanacs. The etchings were numerical and notational, he argued. On a bone shard from a prehistoric settlement called Abri Blanchard in France, dating to 28,000 years ago, he found a pattern of pits, some with commalike curves and some round. He viewed it as a record of lunar cycles.

Deeply excited by the find, Marshack soon brought his conclusions to archaeologists and anthropologists throughout Europe and the United States. Some of these experts were impressed, according to accounts at the time.

Hunters who could figure out when the night would be illuminated by moonlight would have had an “adaptive advantage,” Aveni says. “That is so much what the cave paintings are about,” he says, referring to the tally marks near the animals on the walls of the Chauvet Cave in France and elsewhere.

Regarding Marshack’s speculations about the Blanchard bone shard, paleoanthropologist Ian Tattersall is still unsure. “We know Ice Age European art was highly symbolic, and there is no doubt that [ancient people] perceived symbols all around them in nature. And it is pretty certain that the moon played a huge role in their cosmology, and that they were fully aware of its cycle,” says Tattersall, curator emeritus of human origins at the American Museum of Natural History in New York City. “Beyond that, all bets are off.”

Thirteen notches
In the decades after Marshack published his findings, historians and anthropologists began noticing similar lunar motifs throughout the archaeological record of this time period and afterward, Aveni notes. “There are more than one of these items that have markings on them that might relate to the moon,” he says.

The Venus of Laussel is one extraordinary example. It is a carving of a voluptuous woman, one hand resting on her abdomen, the other raised and holding a bison horn etched with 13 notches. Her face is turned toward the horn. The figure was carved between 22,000 and 27,000 years ago, in a rock-shelter in the Dordogne region of southwestern France.
Some archaeologists now think the 13 notches represent the number of lunar cycles in a solar year — and, approximately, the average number of menstrual cycles. Though modern scientists have debunked any direct connection between the cycles of the moon and human fertility, ancient people would have recognized the parallel timing; the lunar cycle repeats every 29.5 days, roughly the same schedule as the average woman’s menstrual cycle. People of 30,000 years ago could have used the moon and stars to plan their pregnancies, Rappenglück speculates.

Cave paintings in the Dordogne region may be depictions of the lunar and menstrual cycles. Specifically, the Lascaux cave paintings, dating to 17,000 years ago, are best known for their curvy, sweeping depictions of horses and bulls. Beyond the cave entrance, past what is called the Hall of Bulls, is a dead-end passage called the Axial Gallery. Red aurochs, an extinct form of cattle, stand in a group. A huge black bull stands apart from them. Across the gallery, a pregnant horse gallops above a row of 26 black dots. The mare is running toward a massive stag, with front legs invisible behind 13 additional evenly spaced dots.

The animals may represent seasons, Rappenglück suggests. In Europe, bovines calve in the spring; horses both foal and mate in the late spring. The deer rut takes place in early autumn, and the wild goats known as ibex mate around the winter solstice.

To Rappenglück, the dots depict the 13 full moons of the lunar cycle. The 26 dots may roughly represent the days of a sidereal month, or the time it takes the moon to return to the same position in the sky relative to the stars. “The striking row of dots is a kind of a time-unit,” he wrote in 2004.

Critics have said Marshack’s work overinterprets many artifacts from Africa and Europe, some of which contain markings at the limit of naked-eye visibility (SN: 6/9/90, p. 357).

“By modern standards of evidence, he is playing with numerological coincidences,” art historian James Elkins wrote in 1996 in an article that is part critique and part celebration. Elkins noted that Marshack countered his doubters by throwing their uncertainty back at them, arguing that better explanations were lacking.

“Nights were real nights at that time, and Paleolithic people certainly had deep insights into what was going on in the sky,” says Harald Floss, an anthropologist at the University of Tübingen in Germany who studies the origin of art. “But I would not risk saying more.”

Celebrate the moon landing anniversary with books that go beyond the small step

Astronomy lovers are not the only ones excited about the 50th anniversary of the moon landing. Publishers are also taking note, serving up a pile of books to mark the occasion.

Are you looking for a general overview of the birth of the U.S. space program? Would you rather geek out on the technical details of the Apollo missions? How about flipping through a collection of photographs from the era? Science News staff took a look at the offerings and picked out a few favorites to help you decide. There’s something for everyone in the list below.
For history aficionados
James Donovan
Little, Brown and Co., $30

This retelling of the space race begins with the launch of the Soviet Union’s Sputnik satellite in 1957 and culminates in the historic Apollo 11 mission 12 years later. The book offers insights into the personalities of the astronauts, engineers and others who made the U.S. space program a success.
For detail-obsessed NASA fans
Charles Fishman
Simon & Schuster, $29.99

Getting to the moon demanded a million hours of work for each hour spent in space, this book argues. Accordingly, the story focuses on the engineers, coders, project managers and others who toiled to get the Apollo program off the ground.
For anyone who ever dreamed of being an astronaut
J.L. Pickering and John Bisney
Univ. of Florida, $45

Packed with hundreds of photos, some published for the first time, this coffee-table book reads like a photo album of the Apollo 11 mission. The images focus on candid moments from astronaut training, as well as the excitement of liftoff, the historic landing and the return home of the three men.

For readers ready for a sober view of Apollo
Roger D. Launius
Smithsonian Books, $27.95

A space historian takes the Apollo program off its pedestal to examine it from multiple angles: as a cog in the Cold War political machine, an engineering endeavor riddled with as many failures as feats of glory and an iconic cultural moment. The book explores both positive and negative viewpoints on the U.S. moonshot project from scientists, politicians, the media and the public during the space race and beyond.

For fans of graphic novels
Jonathan Fetter-Vorm
Hill and Wang, $35

Colorful and detailed, the comic-style illustrations in this book of graphic nonfiction bring the moon landing to life. Much of the astronauts’ dialog is based on real recordings, making the book feel particularly authentic.

For self-improvement buffs
Richard Wiseman
TarcherPerigee, $26

A psychologist takes practical lessons from the Apollo era and suggests ways to apply them to everyday problems, from changing careers to raising a family.

For space enthusiasts
David Baker
Arcturus Publishing Limited, $19.99

A former NASA engineer uses photographs, illustrations, blueprints and other documents to guide readers through a concise history of the space race and the Apollo program, from the beginnings of rocket science to the successful return home of the Apollo 11 crew.

For history wonks with a soft spot for psychology
Basil Hero
Grand Central Publishing, $22

The Apollo astronauts rarely gave personal interviews. But now that they’re getting older, the astronauts are starting to get introspective. This book distills conversations with the 12 lunar voyagers still alive into general wisdom on conquering fear and appreciating life.

For photography lovers
Deborah Ireland
Ammonite Press, $14.95

This slim book offers an offbeat take on the mission to the moon, telling the story of the Apollo program through the development of the Hasselblad cameras that Neil Armstrong and Buzz Aldrin used to document their time on the lunar surface.
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