Chinese experts have criticized Germany's decision to cease granting promotional loans to China and deny China's developing country status, calling it a move that succumbs to pressure from the US' cold-war mentality toward China. They warn that Germany risks undermining its own economic interests and damaging the investment confidence of European enterprises in China.

Germany will no longer grant promotional loans to China from 2026 and no longer treat China as a developing country, the Federal Development Ministry (BMZ) confirmed on Tuesday. 

The German ministry said it has informed the Chinese Ministry of Finance in mid-September of the federal government's decision to permanently stop granting promotional loans to China, Reuters reported.

"We are no longer treating China as a developing country," German Development Minister Svenja Schulze said. "China is and remains an important partner, without whom we cannot successfully overcome global crises," she added.

The move reflects some German politicians' alignment with the US in strengthening "decoupling" from China and creating economic and trade barriers aimed at the country, Chen Jia, an independent analyst on global strategy, told the Global Times on Wednesday.

Under this Cold War mentality, Germany's push to implement a decoupling policy is not beneficial to EU-China cooperation, Chen noted.

Song Wei, a professor at the School of International Relations and Diplomacy at Beijing Foreign Studies University, said Germany's decision to cease granting promotional loans to China and deny China's developing country status was primarily influenced by US attempts to strip China of its developing country status.

For some time, the US has attempted to deprive China of its developing country status, which has been slammed by Chinese officials.

China's status as the world's largest developing country is rooted in facts and international law. It's not up to the US to decide whether China is a developing country, Chinese Foreign Ministry Spokesperson Wang Wenbin said at a press conference in June.
China's status as a developing country is supported by concrete facts. China's per capita GDP in 2022 was $12,741, or one-fifth of that of advanced economies and only one-sixth that of the US. 

The move by Germany will create an atmosphere of uncertainty, hinder the growth of bilateral trade and investment, and dampen the investment confidence of European business in China, experts said.

China and EU just concluded productive talks during the 10th High-level Economic and Trade Dialogue, with the two sides reaching multiple consensuses, China's Ministry of Commerce said in a statement on Tuesday.

Both sides agreed to further promote the two-way opening of the financial industry and encourage eligible financial institutions to invest and expand their business in each other's markets. 

In the context of a global economic downturn, Germany's cancellation of promotional loans will dampen the investment confidence and expectations of European enterprises in the Chinese market, which is not conducive to the deepening economic and trade cooperation between China and Europe, Song said.

From 2013 to 2022, promotional loans with a total volume of 3.451 billion euros ($3.62 billion) were agreed upon with China. No promotional loans were granted in 2023, according to the Reuters report.

Cui Hongjian, a professor with the Academy of Regional and Global Governance with Beijing Foreign Studies University, told the Global Times that these loans primarily support projects related to infrastructure, climate change, environmental protection, and sustainable development. The advantage lies in their relatively fixed and extendable repayment period, as well as the relatively favorable interest rates compared to market rates. 

Cui said that in the future, there may be a shift toward more commercial cooperation rather than policy-driven projects. Additionally, this change may not have a significant impact on large-scale projects, as the Chinese side has sufficient financial capacity for investment, Cui said.

China's major industrial firms saw their profit surge in August, reversing the downward trend and increasing by 17.2 percent from a year earlier, the latest sign of sustained recovery in the world's second-largest economy as stimulus kicks in.

The robust industry growth, which marks the first increase since the second half of 2022, may pave the way for a full rebound as a slew of economic indicators are also pointing to a positive consumption trend during the upcoming Golden Week holidays, observers said.

With consumption and manufacturing activities all in full swing, the domestic economy is expected to ride on the fast track of stabilizing growth, though challenges remain, they noted.

In the first eight months of the year, the profits of major industrial firms with annual main business revenue of at least 20 million yuan ($2.79 million) reached 4.66 trillion yuan, down 11.7 percent year-on-year, with the pace of decline narrowing by 3.8 percentage points from the first seven months, according to data released on Wednesday by the National Bureau of Statistics (NBS).

Of the 41 industrial categories monitored by the bureau, 30 posted better performance in terms of profit during the January-August period, with the losses in raw material manufacturing industry narrowing significantly due to rising commodity prices and recovered demand.

As the country's pro-growth policies continued to show their impact in August, industrial production saw a steady recovery, with the improvement in industrial profit gathering momentum, said NBS statistician Yu Weining.

Profit growth for equipment manufacturing was 3.6 percent for the period, growing from the 1.7 percent registered during the first seven months and leading the overall improvement, Yu said, noting that all business entities recorded better performance.

The reversal in August, reflecting that the overall operating conditions of the industrial sector are improving, was mainly driven by the rebound in market demand, improved prices of industrial products, the effects of macro-support policies, and the low base in 2022, Zhou Maohua, an economist at Everbright Bank, told the Global Times on Wednesday.

The rebound was in line with the momentum of China's official manufacturing purchasing managers' index (PMI) for August, which came in at 49.7, up 0.4 points from the previous month.

A reading below 50 indicates a contraction, while one above 50 indicates expansion.

"The recovery of the PMI represents stable market confidence and projection, and enterprises' profit recovery is the real consequence, which shows that the general situation is improving," Cong Yi, professor at the Tianjin University of Finance and Economics, told the Global Times on Wednesday.

All multiple indicators are upbeat signs for the country's overall economic recovery, and also reflect that a series of supportive measures have taken effect, Cong said.

Notably, in the first eight months of 2023, profit of the electricity, heat generation and supply industry surged by 53.4 percent year-on-year, and profits for electrical machinery and equipment manufacturing increased by 33 percent year-on-year. In addition, profit of auto manufacturing increased by 2.4 percent year-on-year.

NBS data also showed that profit of enterprises in the metal, mineral processing, and energy extraction sectors suffered a decrease, while the profits of coal extraction and washing enterprises declined by 26.3 percent year-on-year, and the profit of chemical raw material and production manufacturing enterprises declined by 51.1 percent.

Structural adjustment of China's industrial enterprises growth is ongoing, and it's a vital period now for shifting the country's economic drive force from traditional industry to emerging sectors, Cong said.

Nevertheless, some domestic industrial manufacturing industries are still in the destocking stage, Zhou said, noting that problems such as insufficient market demand and high cost pressures still pose difficulties for company operations. 

"Domestic macro policy support cannot be relaxed," Zhou said.

Chinese authorities have stressed stronger and more precise measures to bolster the recovery over the past months. In a fresh move on Wednesday, China's central bank said at a quarterly meeting that it would step up policy adjustments and implement monetary policies to expand domestic demand and restore confidence.

During the meeting, the bank emphasized the need to intensify the implementation of existing monetary policies, enhance counter-cyclical and cross-cyclical adjustments, and focus on boosting domestic demand and restoring confidence.

In light of the current domestic and international economic situation, the bank noted that "the current external environment has become more complex and challenging," with inflation remaining high and developed countries expected to maintain elevated interest rates. Additionally, it acknowledged that "the domestic economy continues to recover and improve with strengthened momentum, but still faces challenges such as insufficient demand."

Globally, downward pressure on the world economy has been intensifying. 

According to a Reuters report citing an S&P Global survey, business activity in the US, the world's largest economy, showed little change in September, with the vast services sector essentially idling at the slowest pace since February, and overall new order activity slipping to the lowest level in 2023.

As the 8-day Golden Week holidays approach, tourists are swarming to China's famous landmarks and scenic spots like Tian'anmen Square in Beijing, the Bund in Shanghai, and West Lake in Hangzhou, East China's Zhejiang Province. The vibrant atmosphere, buzzing with excitement and activities, serves as a vivid reflection of the unwavering confidence of the Chinese people in the country's economy and bright future.

An estimated around 800 million travel trips will be made during the eight-day Mid-Autumn Festival and National Day holidays which will kick off on Friday. With record demand for travel and the sustained economic impact of the Asian Games, this year's Golden Week holidays are poised to become the most vibrant and prosperous in recent memory. 

As an important window to observe economic vitality, the upcoming Golden Week holidays will lead a significant consumption rebound in the fourth quarter, playing a crucial role in driving economic growth throughout the entire year, experts said.

Despite downward pressure due to multiple factors, China's consumer market is currently displaying signs of recovery and growth. The resilience, potential, and dynamism of consumption remain strong and unchanged, experts said, refuting Western media and politicians' bearish outlook on Chinese economy.

Hundreds of millions hitting the road

Latest data on holiday travel, accommodation, and tourism products all pointed to a stark rebound from the levels seen in 2019, indicating a remarkable resurgence in consumption activity.

Wednesday marks the first day of the Golden Week holidays travel rush. The railway network in the Yangtze River Delta region is expected to deliver more than 2.5 million passenger trips on Wednesday, 600,000 above the 2019 level, representing growth of over 30 percent, according to China Railway Shanghai Group Co.

According to the China Tourism Academy, over 100 million travel trips will be made per day during the Golden Week holidays, far surpassing the levels of last year and 2019. In terms of commercial aviation, more than 21 million travelers will take flights in the span of eight days and an average of 14,000 domestic flights will be operated per day, up 18 percent from the same period in 2019. China Railway Group forecast that 190 million railway trips will be made during the holidays, up from the 138 million trips seen in 2019.

Hotel bookings for popular destinations have also surged. Data from Qunar showed that domestic hotel bookings for the holidays have increased by 514 percent compared to 2019.

Outbound tourism is expected to see a 20-fold year-on-year increase, according to online traveling platform Trip.com. Travel agency U-tour predicted the number of outbound travelers would exceed this year's May Day holidays by five folds.

According to the National Immigration Administration, the average daily number of inbound and outbound passenger trips during the holidays are expected to reach 1.58 million, three times higher than the same period last year.

Additionally, traveling to Hangzhou, East China's Zhejiang Province has become a spotlight and a unique spark for holidays spending as the eight-day holidays coincide with the main competition days of the Hangzhou Asian Games which last from September 23 to October 8.
Data from the online travel platform Fliggy shows that during the Asian Games, international flight bookings bound for Hangzhou have surged 20 times compared to the same period last year. Train ticket bookings have recorded a 4.7 times year-on-year growth, and hotel bookings near venues have increased by three times compared to last year. The other five cities in the province co-hosting the games also experienced a boom in tourist numbers.

With a substantial surge in bookings for flights, train tickets, accommodations, and tourism products, this holidays break is expected to unleash further consumption potential which vividly illustrates the positive trajectory of the Chinese economy, experts said.

In light of record booking and travel data, indicating a growing consumption enthusiasm, Tian Yun, a Beijing based economist attributed the growth to the lengthier holidays break and spill-out effect of events like the Asian Games, which have injected energy into the economy.
Accelerator of economic growth in Q4

Experts predict that thanks to effective macroeconomic stimulus policies and the boost from the Golden Week holidays, consumption will bounce back strongly in the fourth quarter, playing a crucial role in driving economic growth for the entire year. They have also dismissed smear and bearish outlook painted by some foreign media and Western politicians about the Chinese economy.

China's retail sales, a main gauge of consumption, beat expectations in August thanks to a bumper summer travel peak and consumption-boosting measures, data from the National Bureau of Statistics (NBS) showed.

Driven by the accelerated sales of travel and a wider range of spending options, retail sales of consumer goods in August recorded a year-on-year growth of 4.6 percent to 3.79 trillion yuan ($521.13 billion), 2.1 percentage points higher than the growth rate in the previous month, according to the NBS.

Experts said that the Golden Week holidays and the Asian Games will further accelerate the consumption recovery and economic growth in the fourth quarter, expecting more policy tools to kick in. In addition, the Belt and Road Summit in October and the China International Import Expo in November will both provide a strong boost to China's economy and development.

The extended holiday period provides a significant opportunity for a retail spending peak and is expected to have a significant impact on the GDP growth in the fourth quarter, acting as "an accelerator," Cong Yi, a professor from the Tianjin University of Finance and Economics, told the Global Times on Tuesday.

The Asian Games in particular will be a major boost for consumption-related sectors from sports and culture to catering for the host city and nearby cities in East China's Zhejiang Province as well as the Yangtze River Delta region, Cong added.

According to media reports, citing official information from Zhejiang Province, the preparations for the Asian Games between 2016 and 2020 are estimated to have added about 414.1 billion yuan to Hangzhou's economy, accounting for 7.6 percent of the city's total economic output during that time. It also led to an increase of around 103.3 billion yuan in government revenue, which is about 8.2 percent of the total revenue collected. Additionally, the Games has created job opportunities for approximately 670,000 people, accounting for 2.4 percent of the total employment during that period.

The consumption vitality generated by the Hangzhou Asian Games extends far beyond Hangzhou, with the ripple effect gradually emerging in various parts of Zhejiang Province and even the entire Yangtze River Delta region.

During the Asian Games, hotel bookings in Ningbo, Wenzhou, Huzhou, Shaoxing, and Jinhua cities have all increased by more than fivefold compared to 2019, with Shaoxing experiencing the highest growth rate of 720 percent in hotel bookings.
Beyond the tourism, the sports craze sparked by the Asian Games has ignited the sports economy, sports manufacturing and foreign trade. According to customs data, the export of sports goods from Yiwu, East China's Zhejiang Province reached 5.08 billion yuan in the first eight months of this year, a year-on-year increase of 33 percent.

Tian said that the sustained success of the Asian Games and other major events this year will continue to further drive not only domestic consumption but also international consumption, presenting a window for China's opening-up.

Expert noted that China's consumption potential remains untapped and a massive household saving indicates a significant market for emerging consumer goods and upgraded consumption needs.

By the end of August, the balance of savings deposits for urban and rural residents in China exceeded 7 trillion yuan for the first time, standing at 7.06 trillion yuan.

More can be done to stimulate the consumer market, Tian said, pointing to upgraded consumption demand and new consumption drivers.

New-energy vehicles, domestically produced 5G smartphones, domestically produced large aircraft, and the cruise economy will all become new growth points for China's consumer economy, Tian said.

He is confident that with the government's efforts, the gradual recovery of individuals from the pandemic's impact, the retail sales growth could reach 6 percent in the fourth quarter.

"It is expected that macro policies will focus on creating more jobs and promoting economic growth in the fourth quarter. It will also address long-term issues like aged care to boost market confidence," Tian said.
Li Yong, president of Chongqing Frontier Regional Economic Research Institute, told the Global Times that stimulating consumer spending through the issuance of shopping vouchers is a good method, especially for the catering and tourism sectors, which will encourage people to visit malls and take trips.

Experts also defied attacks by some Western politicians and media outlets that paint the Chinese economy as being at the cusp of collapse.

Cong dismissed smear from foreign media, as the trend of consumption upgrading in China's massive market of 1.4 billion people remains unchanged. He also noted that the bearish view on the Chinese economy is a long-standing line of attack from sections of the Western media, yet it has never managed to drag down China's economy.

"China is well on track to achieve the GDP growth target of around 5 percent for the whole year, and the final quarter growth will solidify the target," Cong said.

Tian predicted China's economic growth to grow at around 5.2 percent for this year.

"Actions speak louder than words. As China remains focused on its economic work, progressing at its own pace and avoiding empty rhetoric, there is no need to pay attention to Western attempts to discredit it," Li said, predicting China's economic growth would finish in a range of 5 percent to 5.2 percent this year.

A man with a hole in his forehead, who was interred in what’s now northwest Alabama between around 3,000 and 5,000 years ago, represents North America’s oldest known case of skull surgery.

Damage around the man’s oval skull opening indicates that someone scraped out that piece of bone, probably to reduce brain swelling caused by a violent attack or a serious fall, said bioarchaeologist Diana Simpson of the University of Nevada, Las Vegas. Either scenario could explain fractures and other injuries above the man’s left eye and to his left arm, leg and collarbone.

Bone regrowth on the edges of the skull opening indicates that the man lived for up to one year after surgery, Simpson estimated. She presented her analysis of the man’s remains on March 28 at a virtual session of the annual meeting of the American Association of Biological Anthropologists.
Skull surgery occurred as early as 13,000 years ago in North Africa (SN: 8/17/11). Until now, the oldest evidence of this practice in North America dated to no more than roughly 1,000 years ago.

In his prime, the new record holder likely served as a ritual practitioner or shaman. His grave included items like those found in shamans’ graves at nearby North American hunter-gatherer sites dating to between about 3,000 and 5,000 years ago. Ritual objects buried with him included sharpened bone pins and modified deer and turkey bones that may have been tattooing tools (SN: 5/25/21).

Investigators excavated the man’s grave and 162 others at the Little Bear Creek Site, a seashell covered burial mound, in the 1940s. Simpson studied the man’s museum-held skeleton and grave items in 2018, shortly before the discoveries were returned to local Native American communities for reburial.

Science, some would say, is an enterprise that should concern itself solely with cold, hard facts. Flights of imagination should be the province of philosophers and poets.

On the other hand, as Albert Einstein so astutely observed, “Imagination is more important than knowledge.” Knowledge, he said, is limited to what we know now, while “imagination embraces the entire world, stimulating progress.”

So with science, imagination has often been the prelude to transformative advances in knowledge, remaking humankind’s understanding of the world and enabling powerful new technologies.
And yet while sometimes spectacularly successful, imagination has also frequently failed in ways that retard the revealing of nature’s secrets. Some minds, it seems, are simply incapable of imagining that there’s more to reality than what they already know.

On many occasions scientists have failed to foresee ways of testing novel ideas, ridiculing them as unverifiable and therefore unscientific. Consequently it is not too challenging to come up with enough failures of scientific imagination to compile a Top 10 list, beginning with:

10. Atoms
    By the middle of the 19th century, most scientists believed in atoms. Chemists especially. John Dalton had shown that the simple ratios of different elements making up chemical compounds strongly implied that each element consisted of identical tiny particles. Subsequent research on the weights of those atoms made their reality pretty hard to dispute. But that didn’t deter physicist-philosopher Ernst Mach. Even as late as the beginning of the 20th century, he and a number of others insisted that atoms could not be real, as they were not accessible to the senses. Mach believed that atoms were a “mental artifice,” convenient fictions that helped in calculating the outcomes of chemical reactions. “Have you ever seen one?” he would ask.

Apart from the fallacy of defining reality as “observable,” Mach’s main failure was his inability to imagine a way that atoms could be observed. Even after Einstein proved the existence of atoms by indirect means in 1905, Mach stood his ground. He was unaware, of course, of the 20th century technologies that quantum mechanics would enable, and so did not foresee powerful new microscopes that could show actual images of atoms (and allow a certain computing company to drag them around to spell out IBM).

9. Composition of stars
   Mach’s views were similar to those of Auguste Comte, a French philosopher who originated the idea of positivism, which denies reality to anything other than objects of sensory experience. Comte’s philosophy led (and in some cases still leads) many scientists astray. His greatest failure of imagination was an example he offered for what science could never know: the chemical composition of the stars.

Unable to imagine anybody affording a ticket on some entrepreneur’s space rocket, Comte argued in 1835 that the identity of the stars’ components would forever remain beyond human knowledge. We could study their size, shapes and movements, he said, “whereas we would never know how to study by any means their chemical composition, or their mineralogical structure,” or for that matter, their temperature, which “will necessarily always be concealed from us.”

Within a few decades, though, a newfangled technology called spectroscopy enabled astronomers to analyze the colors of light emitted by stars. And since each chemical element emits (or absorbs) precise colors (or frequencies) of light, each set of colors is like a chemical fingerprint, an infallible indicator for an element’s identity. Using a spectroscope to observe starlight therefore can reveal the chemistry of the stars, exactly what Comte thought impossible.

8. Canals on Mars
   Sometimes imagination fails because of its overabundance rather than absence. In the case of the never-ending drama over the possibility of life on Mars, that planet’s famous canals turned out to be figments of overactive scientific imagination.

First “observed” in the late 19th century, the Martian canals showed up as streaks on the planet’s surface, described as canali by Italian astronomer Giovanni Schiaparelli. Canali is, however, Italian for channels, not canals. So in this case something was gained (rather than lost) in translation — the idea that Mars was inhabited. “Canals are dug,” remarked British astronomer Norman Lockyer in 1901, “ergo there were diggers.” Soon astronomers imagined an elaborate system of canals transporting water from Martian poles to thirsty metropolitan areas and agricultural centers. (Some observers even imagined seeing canals on Venus and Mercury.)
With more constrained imaginations, aided by better telescopes and translations, belief in the Martian canals eventually faded. It was merely the Martian winds blowing dust (bright) and sand (dark) around the surface in ways that occasionally made bright and dark streaks line up in a deceptive manner — to eyes attached to overly imaginative brains.

7. Nuclear fission
   In 1934, Italian physicist Enrico Fermi bombarded uranium (atomic number 92) and other elements with neutrons, the particle discovered just two years earlier by James Chadwick. Fermi found that among the products was an unidentifiable new element. He thought he had created element 93, heavier than uranium. He could not imagine any other explanation. In 1938 Fermi was awarded the Nobel Prize in physics for demonstrating “the existence of new radioactive elements produced by neutron irradiation.”

It turned out, however, that Fermi had unwittingly demonstrated nuclear fission. His bombardment products were actually lighter, previously known elements — fragments split from the heavy uranium nucleus. Of course, the scientists later credited with discovering fission, Otto Hahn and Fritz Strassmann, didn’t understand their results either. Hahn’s former collaborator Lise Meitner was the one who explained what they’d done. Another woman, chemist Ida Noddack, had imagined the possibility of fission to explain Fermi’s results, but for some reason nobody listened to her.

6. Detecting neutrinos
   In the 1920s, most physicists had convinced themselves that nature was built from just two basic particles: positively charged protons and negatively charged electrons. Some had, however, imagined the possibility of a particle with no electric charge. One specific proposal for such a particle came in 1930 from Austrian physicist Wolfgang Pauli. He suggested that a no-charge particle could explain a suspicious loss of energy observed in beta-particle radioactivity. Pauli’s idea was worked out mathematically by Fermi, who named the neutral particle the neutrino. Fermi’s math was then examined by physicists Hans Bethe and Rudolf Peierls, who deduced that the neutrino would zip through matter so easily that there was no imaginable way of detecting its existence (short of building a tank of liquid hydrogen 6 million billion miles wide). “There is no practically possible way of observing the neutrino,” Bethe and Peierls concluded.

But they had failed to imagine the possibility of finding a source of huge numbers of high-energy neutrinos, so that a few could be captured even if almost all escaped. No such source was known until nuclear fission reactors were invented. In the 1950s, Frederick Reines and Clyde Cowan used reactors to definitely establish the neutrino’s existence. Reines later said he sought a way to detect the neutrino precisely because everybody had told him it wasn’t possible to detect the neutrino.

5. Nuclear energy
   Ernest Rutherford, one of the 20th century’s greatest experimental physicists, was not exactly unimaginative. He imagined the existence of the neutron a dozen years before it was discovered, and he figured out that a weird experiment conducted by his assistants had revealed that atoms contained a dense central nucleus. It was clear that the atomic nucleus packed an enormous quantity of energy, but Rutherford could imagine no way to extract that energy for practical purposes. In 1933, at a meeting of the British Association for the Advancement of Science, he noted that although the nucleus contained a lot of energy, it would also require energy to release it. Anyone saying we can exploit atomic energy “is talking moonshine,” Rutherford declared. To be fair, Rutherford qualified the moonshine remark by saying “with our present knowledge,” so in a way he perhaps was anticipating the discovery of nuclear fission a few years later. (And some historians have suggested that Rutherford did imagine the powerful release of nuclear energy, but thought it was a bad idea and wanted to discourage people from attempting it.)
6. Age of the Earth
   Rutherford’s reputation for imagination was bolstered by his inference that radioactive matter deep underground could solve the mystery of the age of the Earth. In the mid-19th century, William Thomson (later known as Lord Kelvin) calculated the Earth’s age to be something a little more than 100 million years, and possibly much less. Geologists insisted that the Earth must be much older — perhaps billions of years — to account for the planet’s geological features.

Kelvin calculated his estimate assuming the Earth was born as a molten rocky mass that then cooled to its present temperature. But following the discovery of radioactivity at the end of the 19th century, Rutherford pointed out that it provided a new source of heat in the Earth’s interior. While giving a talk (in Kelvin’s presence), Rutherford suggested that Kelvin had basically prophesized a new source of planetary heat.

While Kelvin’s neglect of radioactivity is the standard story, a more thorough analysis shows that adding that heat to his math would not have changed his estimate very much. Rather, Kelvin’s mistake was assuming the interior to be rigid. John Perry (one of Kelvin’s former assistants) showed in 1895 that the flow of heat deep within the Earth’s interior would alter Kelvin’s calculations considerably — enough to allow the Earth to be billions of years old. It turned out that the Earth’s mantle is fluid on long time scales, which not only explains the age of the Earth, but also plate tectonics.

3. Charge-parity violation
   Before the mid-1950s, nobody imagined that the laws of physics gave a hoot about handedness. The same laws should govern matter in action when viewed straight-on or in a mirror, just as the rules of baseball applied equally to Ted Williams and Willie Mays, not to mention Mickey Mantle. But in 1956 physicists Tsung-Dao Lee and Chen Ning Yang suggested that perfect right-left symmetry (or “parity”) might be violated by the weak nuclear force, and experiments soon confirmed their suspicion.

Restoring sanity to nature, many physicists thought, required antimatter. If you just switched left with right (mirror image), some subatomic processes exhibited a preferred handedness. But if you also replaced matter with antimatter (switching electric charge), left-right balance would be restored. In other words, reversing both charge (C) and parity (P) left nature’s behavior unchanged, a principle known as CP symmetry. CP symmetry had to be perfectly exact; otherwise nature’s laws would change if you went backward (instead of forward) in time, and nobody could imagine that.

In the early 1960s, James Cronin and Val Fitch tested CP symmetry’s perfection by studying subatomic particles called kaons and their antimatter counterparts. Kaons and antikaons both have zero charge but are not identical, because they are made from different quarks. Thanks to the quirky rules of quantum mechanics, kaons can turn into antikaons and vice versa. If CP symmetry is exact, each should turn into the other equally often. But Cronin and Fitch found that antikaons turn into kaons more often than the other way around. And that implied that nature’s laws allowed a preferred direction of time. “People didn’t want to believe it,” Cronin said in a 1999 interview. Most physicists do believe it today, but the implications of CP violation for the nature of time and other cosmic questions remain mysterious.

2. Behaviorism versus the brain
   In the early 20th century, the dogma of behaviorism, initiated by John Watson and championed a little later by B.F. Skinner, ensnared psychologists in a paradigm that literally excised imagination from science. The brain — site of all imagination — is a “black box,” the behaviorists insisted. Rules of human psychology (mostly inferred from experiments with rats and pigeons) could be scientifically established only by observing behavior. It was scientifically meaningless to inquire into the inner workings of the brain that directed such behavior, as those workings were in principle inaccessible to human observation. In other words, activity inside the brain was deemed scientifically irrelevant because it could not be observed. “When what a person does [is] attributed to what is going on inside him,” Skinner proclaimed, “investigation is brought to an end.”

Skinner’s behaviorist BS brainwashed a generation or two of followers into thinking the brain was beyond study. But fortunately for neuroscience, some physicists foresaw methods for observing neural activity in the brain without splitting the skull open, exhibiting imagination that the behaviorists lacked. In the 1970s Michel Ter-Pogossian, Michael Phelps and colleagues developed PET (positron emission tomography) scanning technology, which uses radioactive tracers to monitor brain activity. PET scanning is now complemented by magnetic resonance imaging, based on ideas developed in the 1930s and 1940s by physicists I.I. Rabi, Edward Purcell and Felix Bloch.

1. Gravitational waves
   Nowadays astrophysicists are all agog about gravitational waves, which can reveal all sorts of secrets about what goes on in the distant universe. All hail Einstein, whose theory of gravity — general relativity — explains the waves’ existence. But Einstein was not the first to propose the idea. In the 19th century, James Clerk Maxwell devised the math explaining electromagnetic waves, and speculated that gravity might similarly induce waves in a gravitational field. He couldn’t figure out how, though. Later other scientists, including Oliver Heaviside and Henri Poincaré, speculated about gravity waves. So the possibility of their existence certainly had been imagined.

But many physicists doubted that the waves existed, or if they did, could not imagine any way of proving it. Shortly before Einstein completed his general relativity theory, German physicist Gustav Mie declared that “the gravitational radiation emitted … by any oscillating mass particle is so extraordinarily weak that it is unthinkable ever to detect it by any means whatsoever.” Even Einstein had no idea how to detect gravitational waves, although he worked out the math describing them in a 1918 paper. In 1936 he decided that general relativity did not predict gravitational waves at all. But the paper rejecting them was simply wrong.
As it turned out, of course, gravitational waves are real and can be detected. At first they were verified indirectly, by the diminishing distance between mutually orbiting pulsars. And more recently they were directly detected by huge experiments relying on lasers. Nobody had been able to imagine detecting gravitational waves a century ago because nobody had imagined the existence of pulsars or lasers.

All these failures show how prejudice can sometimes dull the imagination. But they also show how an imagination failure can inspire the quest for a new success. And that’s why science, so often detoured by dogma, still manages somehow, on long enough time scales, to provide technological wonders and cosmic insights beyond philosophers’ and poets’ wildest imagination.

It’s a weird time in the pandemic. COVID-19 cases are once again climbing in some parts of the United States, but still falling from the January surge in other places. The omicron subvariant BA.2 is now dominant in the country, accounting for more than 50 percent of new cases in the week ending March 26, according to the U.S. Centers for Disease Control and Prevention.

BA.2 has already taken parts of the world by storm, spurring large outbreaks in Europe and Asia. With the rising spread of the subvariant in the United States, signs are pointing to another COVID-19 wave here, although it’s unclear how big it could be. There is a good amount of immunity from vaccination and infections from other omicron siblings to help flatten the next peak. But the highly transmissible subvariant is advancing at a time when many have tossed masks aside.

I can’t help but feel that we’re sitting ducks. There’s no movement yet to reinstate protective measures to prepare for the coming wave. Instead, there are loud calls to “return to normal.” But even though it’s been two years, this pandemic isn’t over, no matter how much we wish it were. And when people talk about “normal,” I am struck by what can’t be “normal” again.
For millions and millions of people who have lost children, partners, parents and friends, life won’t be the same. One study reported that the “mortality shock” of COVID-19 has left nine people bereaved for every one U.S. death. So for the more than 975,000 who have died of COVID-19 in the United States, there are close to 9 million who are grieving. Although the study didn’t calculate the ratio globally, more than 6 million have died worldwide, undoubtedly leaving tens of millions bereaved. At the global scale, researchers estimate that through October 2021, more than 5 million children have lost a parent or caregiver to COVID-19, putting these children’s health, development and future education at risk (SN: 2/24/22).

Adding to the loss, the pandemic robbed many people of the chance to be with their loved ones as they died or to gather for a funeral. Psychiatrists are concerned that cases of prolonged grief disorder could rise, considering the scale of this mass mourning event.

Many millions who weathered an infection with SARS-CoV-2 went on to develop debilitating symptoms from long COVID, preventing their return to “normal.” A recent report from the U.S. Government Accountability Office estimates that 7.7 to 23 million people in the United States may have developed the condition. Worldwide, an estimated 100 million people currently have, or have had, long-term symptoms from COVID-19, researchers reported in a preprint study last November. Many with long COVID can no longer work and are struggling to get financial assistance in the United States. Some have lost their homes.

And as masking and vaccine mandates have fallen away, people with compromised immune systems have no choice but to fend for themselves and remain vigilant about restricting their interactions. People taking drugs that suppress the immune system or who have immune system disorders can’t muster much protection, if any, following vaccination against the coronavirus. And if they get COVID-19, their weakened defenses put them at risk of more severe disease.
With all that people have endured — and continue to endure — during the pandemic, it would be a colossal missed opportunity to throw aside what we’ve learned from this experience. The pandemic brought wider attention to how racism fuels health disparities in the United States and renewed calls to make more progress dismantling inequities. With remote work and virtual school, many people with disabilities have gained important accommodations. The argument that internet access is a social determinant of health has been reinforced: Places that had limited access to broadband internet were associated with higher COVID-19 mortality rates in the United States, researchers reported this month in JAMA Network Open.

The pandemic could also provide the push to bring indoor air under public health’s wing, joining common goods like water and food. The recognition that the virus that causes COVID-19 is primarily spread through the air has also been a reminder of the airborne risk posed by other respiratory diseases, including influenza and tuberculosis (SN: 12/16/21). Improved ventilation — bringing fresh outdoor air inside — can temper an influenza outbreak, and it helped to control a real-world tuberculosis outbreak in Taiwan.

Paying attention to indoor air quality has also paid dividends during the COVID-19 pandemic. Schools that combined better ventilation with high-efficiency filters reduced the incidence of COVID-19 by 48 percent compared with schools that didn’t, researchers reported last year. This month, the Fondazione David Hume released not-yet-peer-reviewed results of an experiment in the Marche Region in Italy that looked at schools with and without controlled mechanical ventilation and the impact of different rates of air exchange. Replacing the air in a classroom 2.4 times per hour reduced the risk of COVID-19 spread by a factor of 1.7. More frequent exchanges reduced the risk even more, up to a factor of 5.7 with replacement 6 times an hour.
British scientists who advise the U.K. government would like buildings to display signs to inform the public of the status of the air inside. They have developed prototype placards with different icons and color-coding schemes to convey information such as whether a room is mechanically ventilated, uses filtration or monitors carbon dioxide, which is a proxy for how much fresh air a room gets. The group is testing options in a pilot program.

In the United States, the White House has launched the Clean Air in Buildings Challenge as part of the National COVID-19 Preparedness Plan. The Biden administration and Congress have made federal funding available to improve air quality in schools, public buildings and other structures. The Environmental Protection Agency has released recommendations on how to plan for and take action on indoor air quality.

“Healthy and clean indoor air should become an expectation for all of us,” Alondra Nelson, head of the White House Office of Science and Technology Policy, said at a webinar about the new initiatives on March 29. “It’s just as important as the food we eat and the water we drink.”

Making clean indoor air a public health priority, and putting in the work and money to make it a reality across the country, would go a long way to helping us prepare for infectious disease outbreaks to come. It also reinforces the public in public health, a commitment to protecting as many people as possible, just as masking mandates at appropriate times do. It’s how we get to some kind of “normal” that everyone can share in.

Buried within the Las Pinturas pyramid in San Bartolo, Guatemala, thousands of painted plaster mural fragments offer a window into ancient Maya civilization. Two of those fragments form the earliest known record of a Maya calendar, created between 300 and 200 B.C.

The fragments depict the date of “7 Deer” from the 260-day sacred calendar common across ancient Mesoamerica and still used today by indigenous communities in Guatemala and southern Mexico, archaeologist David Stuart and colleagues report April 13 in Science Advances. The calendar system’s longevity attests to the persistence of Maya intellectual culture, says Stuart, of the University of Texas at Austin.

From 400 B.C. to 100 A.D., Mayas razed and rebuilt the pyramid seven times, creating a series of discrete time capsules stacked on top of each other, says study coauthor Heather Hurst, project director of the San Bartolo-Xultun Regional Archaeological Project. By radiocarbon dating both the material in the layer where the calendar fragments were found and the material used to bury that layer, researchers determined a narrow time window in which the 7 Deer day record would have been produced.
After two decades of excavation, the site continues to be an important source of ancient Maya artifacts. The earliest known Maya writing, also dated to between 300 and 200 B.C., was found in the same time capsule as the 7 Deer day record (SN: 1/17/06).

The 260-day calendar system “survived not only close to 1,800 years in the Maya world before the Spanish showed up, but it persisted even more recently, since conquests . . . in some of the most oppressed areas,” Stuart says. “I find that an incredible thing.”

In fact, the intricacy of the depiction suggests that the calendar system had already existed for centuries by the time it was drawn, says Stephen Houston, an archaeologist at Brown University in Providence, R.I., who was not involved in the study. The characters are “very well practiced. This isn’t a stumbling baby step.”

Ten other fragments described in the study feature different styles of handwriting that indicate multiple scribes worked on the murals. This suggests that the Maya literary tradition was already robust by this time, Houston says. “There’s a density of knowledge here.”

Deep in the human brain, a very specific kind of cell dies during Parkinson’s disease.

For the first time, researchers have sorted large numbers of human brain cells in the substantia nigra into 10 distinct types. Just one is especially vulnerable in Parkinson’s disease, the team reports May 5 in Nature Neuroscience. The result could lead to a clearer view of how Parkinson’s takes hold, and perhaps even ways to stop it.

The new research “goes right to the core of the matter,” says neuroscientist Raj Awatramani of Northwestern University Feinberg School of Medicine in Chicago. Pinpointing the brain cells that seem to be especially susceptible to the devastating disease is “the strength of this paper,” says Awatramani, who was not involved in the study.

Parkinson’s disease steals people’s ability to move smoothly, leaving balance problems, tremors and rigidity. In the United States, nearly 1 million people are estimated to have Parkinson’s. Scientists have known for decades that these symptoms come with the death of nerve cells in the substantia nigra. Neurons there churn out dopamine, a chemical signal involved in movement, among other jobs (SN: 9/7/17).

But those dopamine-making neurons are not all equally vulnerable in Parkinson’s, it turns out.

“This seemed like an opportunity to … really clarify which kinds of cells are actually dying in Parkinson’s disease,” says Evan Macosko, a psychiatrist and neuroscientist at Massachusetts General Hospital in Boston and the Broad Institute of MIT and Harvard.
The tricky part was that dopamine-making neurons in the substantia nigra are rare. In samples of postmortem brains, “we couldn’t survey enough of [the cells] to really get an answer,” Macosko says. But Abdulraouf Abdulraouf, a researcher in Macosko’s laboratory, led experiments that sorted these cells, figuring out a way to selectively pull the cells’ nuclei out from the rest of the cells present in the substantia nigra. That enrichment ultimately led to an abundance of nuclei to analyze.

By studying over 15,000 nuclei from the brains of eight formerly healthy people, the researchers further sorted dopamine-making cells in the substantia nigra into 10 distinct groups. Each of these cell groups was defined by a specific brain location and certain combinations of genes that were active.

When the researchers looked at substantia nigra neurons in the brains of people who died with either Parkinson’s disease or the related Lewy body dementia, the team noticed something curious: One of these 10 cell types was drastically diminished.

These missing neurons were identified by their location in the lower part of the substantia nigra and an active AGTR1 gene, lab member Tushar Kamath and colleagues found. That gene was thought to serve simply as a good way to identify these cells, Macosko says; researchers don’t know whether the gene has a role in these dopamine-making cells’ fate in people.

The new finding points to ways to perhaps counter the debilitating diseases. Scientists have been keen to replace the missing dopamine-making neurons in the brains of people with Parkinson’s. The new study shows what those cells would need to look like, Awatramani says. “If a particular subtype is more vulnerable in Parkinson’s disease, maybe that’s the one we should be trying to replace,” he says.

In fact, Macosko says that stem cell scientists have already been in contact, eager to make these specific cells. “We hope this is a guidepost,” Macosko says.

The new study involved only a small number of human brains. Going forward, Macosko and his colleagues hope to study more brains, and more parts of those brains. “We were able to get some pretty interesting insights with a relatively small number of people,” he says. “When we get to larger numbers of people with other kinds of diseases, I think we’re going to learn a lot.”

For many recreational runners, taking a jog is a fun way to stay fit and burn calories. But it turns out an individual has a tendency to settle into the same, comfortable pace on short and long runs — and that pace is the one that minimizes their body’s energy use over a given distance.

“I was really surprised,” says Jessica Selinger, a biomechanist at Queen’s University in Kingston, Canada. “Intuitively, I would have thought people run faster at shorter distances and slow their pace at longer distances.”

Selinger and colleagues combined data from more than 4,600 runners, who went on 37,201 runs while wearing a fitness device called the Lumo Run, with lab-based physiology data. The analysis, described April 28 in Current Biology, also shows that it takes more energy for someone to run a given distance if they run faster or slower than their optimum speed.
“There is a speed that for you is going to feel the best,” Selinger says. “That speed is the one where you’re actually burning fewer calories.”

The runners ranged in age from 16 to 83, and had body mass indices spanning from 14.3 to 45.4. But no matter participants’ age, weight or sex — or whether they ran only a narrow range of distances or runs of varying lengths — the same pattern showed up in the data repeatedly.

Researchers have thought that running was performance-driven, says Melissa Thompson, a biomechanist at Fort Lewis College in Durango, Colo., who was not involved in the new study. This new research, she says, is “talking about preference, not performance.”

Most related research, Selinger says, has been done in university laboratories, with study subjects who are generally younger and healthier than the general population. By using wearable devices, the researchers could track many more runs, across more real-life conditions than is possible in a lab. That allowed the scientists to look at a “much broader cross section of humanity,” she says. Treadmill tests measuring energy use at different paces with people representative of those included in the fitness tracker data were used to determine optimum energy-efficient speeds.

Because the study includes a wide range of conditions and doesn’t control for things like fasting before running, it’s messier than data gathered in labs. Still, the sheer volume of real-world runs recorded by the wearable devices supports a convincing general rule about how humans run, says Rodger Kram, a physiologist at the University of Colorado Boulder not involved with the study. “I think the rule’s right.”

The results don’t apply to very long runs when fatigue starts to set in, or to race performance by elite athletes or others consciously training for speed. And a runner’s optimum pace can change over time, with training or age for instance.

There are quick tricks for those who want to speed up and go for a little more calorie burn to temporarily trump their body’s natural inclinations: Listen to upbeat music or jog alongside someone with a faster pace, Selinger says. “But it seems like your preference is actually to sink back into that optimum.”

The results match observations of optimum pacing from animals like horses and wildebeests, and also correspond to the way humans tend to walk at a speed that minimizes their individual energy use (SN: 9/10/15).

It does make sense that humans would be adapted to run at an optimum speed for minimizing energy use, says coauthor Scott Delp, a biomechanist at Stanford University. Imagine being an early human ancestor going out to hunt difficult prey. “It might be days before I get my next food,” he says. “So I want to spend the least energy en route to getting that food.”