Can’t comb your kid’s hair? This gene may be to blame

The flurry of frizzy-hair e-mails began in 2016.

Human geneticist Regina Betz of University Hospital Bonn in Germany and her team had just linked three genes to a rare disorder with eye-catching symptoms: silvery, spangly, spun glass hair that just will not lie flat. Called uncombable hair syndrome, patients can have dry, shiny strands that stand away from the scalp like a cloud of dandelion fluff. Only about 100 cases had ever been reported.

But after the study, which looked at 18 cases, people from all over the world reached out. “They said, ‘Oh, I have a child like this’ or, ‘Oh, I looked exactly like that as a child,’” says study coauthor Buket Basmanav, a geneticist also at University Hospital Bonn. “Regina said, ‘Send us your samples.’”
Now, the team has analyzed DNA samples from 107 people with uncombable hair syndrome. Variants of just a single gene accounted for 71 percent of cases, the researchers report August 31 in JAMA Dermatology.

The gene, PADI3, encodes an enzyme involved in hair shaft formation. Mutations in PADI3 can disrupt the process, tinkering with the hair’s structure. In people with the syndrome, the hair shaft is grooved, like “a paper straw that has collapsed in on itself,” says Gillian Westgate, a hair biologist at the University of Bradford in England who was not involved in the study.
Basmanav and her colleagues also linked nearly 4 percent of the cases to variants of TGM3 or TCHH, the two other hair shaft genes that the team had previously studied. Nearly a quarter of the cases in the new study remain genetically unexplained.

The work could help doctors diagnose the disorder, which often improves with age and isn’t typically tied to health problems. Genetically testing kids with the unusually lofty locks might ease the minds of parents worried that their child’s poufy ‘do is a sign of something more serious, Westgate says.

A diagnosis of uncombable hair syndrome can be a relief, Basmanav adds, because “we don’t expect any additional symptoms to show up.”

A carbon footprint life cycle assessment can cut down on greenwashing

Today, you can buy a pair of sneakers partially made from carbon dioxide pulled out of the atmosphere. But measuring the carbon-reduction benefits of making that pair of sneakers with CO2 is complex. There’s the fossil fuel that stayed in the ground, a definite carbon savings. But what about the energy cost of cooling the CO2 into liquid form and transporting it to a production facility? And what about when your kid outgrows the shoes in six months and they can’t be recycled into a new product because those systems aren’t in place yet?

As companies try to reduce their carbon footprint, many are doing life cycle assessments to quantify the full carbon cost of products, from procurement of materials to energy use in manufacturing to product transport to user behavior and end-of-life disposal. It’s a mind-bogglingly difficult metric, but such bean-counting is needed to hold the planet to a livable temperature, says low-carbon systems expert Andrea Ramirez Ramirez of the Delft University of Technology in the Netherlands.
Carbon accounting is easy to get wrong, she says. Differences in starting points for determining a product’s “lifetime” or assumptions about the energy sources can all affect the math.

Carbon use can be reduced at many points along the production chain—by using renewable energy in the manufacturing process, for instance, or by adding atmospheric CO2 to the product. But if other points along the chain are energy-intensive or emit CO2, she notes, the final tally may show a positive rather than a negative number.

A product is carbon negative only when its production actually removes carbon from the environment, temporarily or permanently. The Global CO2 Initiative, with European and American universities, has created a set of LCA guidelines to standardize measurement so that carbon accounting is consistent and terms such as “carbon neutral” or “carbon negative” have a verifiable meaning.
In the rush to create products that can be touted as fighting climate change, however, some firms have been accused of “greenwashing” – making products or companies appear more environmentally friendly than they really are. Examples of greenwashing, according to a March 2022 analysis by mechanical engineers Grant Faber and Volker Sick of the University of Michigan in Ann Arbor include labeling plastic garbage bags as recyclable when their whole purpose is to be thrown away; using labels such as “eco-friendly” or “100% Natural” without official certification; and claiming a better carbon footprint without acknowledging the existence of even better choices. An example would be “fuel-efficient” sport utility vehicles, which are only fuel efficient when compared with other SUVs rather than with smaller cars, public transit or bicycles.

Good LCA analysis, Sick says, can distinguish companies that are carbon-friendly in name only, from those that are truly helping the world clear the air.

The James Webb telescope spotted CO2 in an exoplanet’s atmosphere

The James Webb Space Telescope has gotten the first sniff of carbon dioxide in the atmosphere of a planet in another solar system.

“It’s incontrovertible. It’s there. It’s definitely there,” says planetary scientist and study coauthor Peter Gao of the Carnegie Institution for Science in Washington, D.C. “There have been hints of carbon dioxide in previous observations, but never confirmed to such an extent.”

The finding, submitted to arXiv.org on August 24, marks the first detailed scientific result published from the new telescope. It also points the way to finding the same greenhouse gas in the atmospheres of smaller, rockier planets that are more like Earth.
The planet, dubbed WASP-39b, is huge and puffy. It’s a bit wider than Jupiter and about as massive as Saturn. And it orbits its star every four Earth days, making it scorching hot. Those features make it a terrible place to search for evidence of extraterrestrial life (SN: 4/19/16). But that combination of puffy atmosphere and frequent passes in front of its star makes it easy to observe, a perfect planet to put the new telescope through its paces.

James Webb, or JWST, launched in December 2021 and released its first images in July 2022 (SN: 7/11/22). For about eight hours in July, the telescope observed starlight that filtered through the planet’s thick atmosphere as the planet crossed between its star and JWST. As it did, molecules of carbon dioxide in the atmosphere absorbed specific wavelengths of that starlight.

Previous observations of WASP-39b with NASA’s now-defunct Spitzer Space Telescope had detected just a whiff of absorption at that same wavelength. But it wasn’t enough to convince astronomers that carbon dioxide was really there.

“I would not have bet more than a beer, at most a six pack, on that weird tentative hint of carbon dioxide from Spitzer,” says astronomer Nicolas Cowan of McGill University in Montreal, who was not involved with the new study. The JWST detection, on the other hand, “is rock solid,” he says. “I wouldn’t bet my firstborn because I love him too much. But I would bet a nice vacation.”

The JWST data also showed an extra bit of absorption at wavelengths close to those absorbed by carbon dioxide. “It’s a mystery molecule,” says astronomer Natalie Batalha of the University of California, Santa Cruz, who led the team behind the observation. “We have several suspects that we are interrogating.”
The amount of carbon dioxide in an exoplanet’s atmosphere can reveal details about how the planet formed (SN: 5/11/18). If the planet was bombarded with asteroids, that could have brought in more carbon and enriched the atmosphere with carbon dioxide. If radiation from the star stripped away some of the planet atmosphere’s lighter elements, that could make it appear richer in carbon dioxide too.

Despite needing a telescope as powerful as JWST to detect it, carbon dioxide might be in atmospheres all over the galaxy, hiding in plain sight. “Carbon dioxide is one of the few molecules that is present in the atmospheres of all solar system planets that have atmospheres,” Batalha says. “It’s your front-line molecule.”

Eventually, astronomers hope to use JWST to find carbon dioxide and other molecules in the atmospheres of small rocky planets, like the ones orbiting the star TRAPPIST-1 (SN: 12/13/17). Some of those planets, at just the right distances from their star to sustain liquid water, might be good places to look for signs of life. It’s yet to be seen whether JWST will detect those signs of life, but it will be able to detect carbon dioxide.

“My first thought when I saw these data was, ‘Wow, this is gonna work,’” Batalha says.