The first look at how archaea package their DNA reveals they’re a lot like us

Single-celled microbes may have taught plants and animals how to pack their genetic baggage.

Archaea, a type of single-celled life-form similar to bacteria, keep their DNA wrapped around proteins much in the same way as more complex organisms, researchers report in the Aug. 11 Science. This finding provides new insight into the evolutionary origins of the DNA-packing process and the secret to archaea’s hardiness, which enables some to live in acid, boiling water or other extreme environments.
All eukaryotes, including plants and animals, store their genetic material in cell compartments called nuclei. Such organisms cram meters of genetic material into the tiny nuclei by wrapping strands of DNA around clusters of proteins called histones (SN: 1/10/15, p. 32). “It doesn’t really matter which eukaryote you look at, whether it’s amoebas or plants or humans or fish or insects or anything,” says coauthor John Reeve, a microbiologist at Ohio State University. “They all have exactly the same structure.”

Unlike bacteria, some archaea also contain histones, but researchers weren’t sure whether these microbes spool DNA around the protein bobbins the way eukaryotes do. So Reeve and colleagues used a method called X-ray crystallography to discern, for the first time, the precise shape of archaea DNA bound to histones.

The researchers saw that archaea DNA coils around the histones, similar to the way it does in eukaryotes. “It’s a big deal actually seeing this,” says Steven Henikoff, a molecular biologist at the Fred Hutchinson Cancer Research Center in Seattle who was not involved in the work. The resemblance between archaea and eukaryote DNA wrapping means that the first organism that used this storage scheme was an ancestor of both modern eukaryotes and archaea, the researchers conclude.

But the way archaea DNA twists around histones isn’t identical to the coils of DNA seen in eukaryotes. In eukaryotes, a strand of DNA loops twice around a cluster of eight histones to create what’s called a nucleosome, and connects many of these nucleosomes like beads on a string. Archaea DNA string together bundles of proteins, too. But while eukaryotes always tether eight-protein clumps, archaea DNA can spiral around stacks of many more histones to create rod-shaped structures of various lengths. “So it’s not as uniform as in eukaryotes,” says coauthor Karolin Luger, a biophysicist and Howard Hughes Medical Institute investigator at the University of Colorado Boulder.

Researchers tested the importance of that rodlike architecture by tampering with the histone-DNA structures of some archaea and then observing how these mutant archaea fared in different conditions. “We tried to mimic some real-life situations that some of these organisms could get into,” Luger says.
For instance, some archaea that live in volcanic vents that emit sulfurous gases sometimes get spewed out and have to survive sans sulfur. Archaea with normal histone-DNA shapes can handle that kind of midlife crisis. But when researchers cut their mutant microbes off sulfur, the microorganisms’ growth was stunted. These microbes may not have been able to adapt to sulfur deprivation as well as their wild counterparts “because they can’t unpackage their DNA as readily if the structure has been changed,” Reeve says.

Henikoff calls it “a pretty cool experiment.” It showed that the archaea’s particular DNA-histone architecture was “biologically relevant, not just a novelty,” he says.

Eclipse watchers will go after the biggest solar mystery: Why is the corona so hot?

A total solar eclipse shines a light on the sun’s elusive atmosphere. When the moon blocks the sun, it’s finally possible to see how this diffuse cloud of plasma, called the corona, is magnetically sculpted into beautiful loops. The material there is about a trillionth the density of the solar surface. From its delicate and diaphanous appearance, you might expect the corona to be where the sun goes to cool off.

That couldn’t be more wrong. The corona is a mysteriously sizzling inferno where the temperature jumps from a mere few thousand degrees to several million degrees. Why?
“It’s one of the longest unanswered questions in all of solar physics,” says Paul Bryans of the High Altitude Observatory at the National Center for Atmospheric Research in Boulder, Colo. “There are a bunch of different ideas about what’s going on there, but it’s still highly debated.” Data collected during the Aug. 21 solar eclipse may bring scientists closer to settling that debate.

The sun simmers at about 5,500° Celsius at its visible surface, the photosphere. But the gas just above the photosphere is heated to about 10,000° C. Then in the corona, the temperature makes an abrupt jump to several million degrees.

“It’s counterintuitive that as you move away from a heat source, it gets warmer,” Bryans says. The corona’s diffuseness makes its heat even stranger — the most basic ways to heat a material rely on particles crashing into each other, but the corona is too tenuous for that to work.

An eclipse first brought this abnormal arrangement to light. German astronomer Walter Grotrian observed spectral lines — the fingerprints of elements that show up when light is split into its component wavelengths — emitted by the corona during a total solar eclipse in 1869.

Astronomers at first assumed those lines were due to a new element they dubbed coronium. But Grotrian realized that iron atoms stripped of several of their electrons by the heat were responsible. These iron lines in the corona are still used to measure its temperature: The more electrons lost, the hotter the material in the corona (SN Online: 6/16/17).
Such extreme temperatures have something to do with the corona’s magnetic field, which is probably where all that energy is stored. Once the energy is there, the corona has a hard time radiating it away, so it builds up. Most of the ways that materials release energy — stripping electrons from atoms, accelerating those electrons so they release X-rays and ultraviolet particles of light — are already maxed out in the corona.
“We know there’s energy coming in, and it’s hard to get it out unless you get very hot,” says Amir Caspi of the Southwest Research Institute in Boulder, Colo. “What we don’t understand is how that energy gets into the corona in the first place.”

Physicists have several ideas. Maybe loops of magnetic field lines in the corona vibrate like guitar strings, heating things up, sort of like how a microwave oven heats food. Maybe the magnetic anchors of those loops on the sun’s surface braid and twist the magnetic field above them, dumping in energy that is then continually radiated away like the heating element in a toaster.

Or maybe tiny explosions called nanoflares or jets called spicules carry energy away from the photosphere and into the corona. The formation of new coronal loops that connect to existing ones could dump in enough extra energy to heat the plasma up.

During the solar eclipse, dozens of groups of scientists across the country will deploy telescopes equipped with filters to pick out polarized light, infrared light or those electron-deprived iron atoms in search of answers. Bryans and his colleagues will be on a mountaintop near Casper, Wyo., in the path of totality. There, the team will take images at a fast clip in both visual and infrared wavelengths to map how the corona changes as the moon moves across the sun. (I will be in Wyoming with this team on the day of the eclipse and will be sharing more about how the experiments went.)

“We can look at how things change as we move from the surface up into the atmosphere,” Bryans says. “How that changes is tied to understanding how the corona is heated.”

Probably all of those mechanisms scientists have thought up contribute to the corona’s extreme heat. It’s difficult to declare just one the most important. But ultimately, the solar eclipse is the best chance scientists have to test them. It’s the only time the corona is the star of the solar show.

The physics of fluids explains how crowds of marathon runners move

Marathoners queuing up for a big race tend to go with the flow, surging toward the start line like a fluid.

Using footage of runners moving in groups toward the start of the Chicago Marathon, researchers developed a theory that treats the crowd like a liquid to explain its movement. The theory correctly predicted the motion of crowds of runners at marathons in two other locations, physicists report in the Jan. 4 Science.

Previous studies have devised rules for how individuals act within a crowd and used that behavior to describe crowd motion (SN: 1/10/15, p. 15). But to understand how wine swirls in a glass, you don’t need to know the behavior of each molecule. So physicists Nicolas Bain and Denis Bartolo of École Normale Supérieure de Lyon in France considered the crowd as a whole.

At the start of a marathon, runners arrange themselves into groups known as corrals, which individually advance to the starting line. Marathon staff members form a line in front of each corral, periodically holding participants back until there’s space to move forward. The researchers filmed this start-and-stop process at four marathons, including the Chicago Marathon in 2016 and 2017. The movements of the staff set off a change in crowd density and speed that traveled through the throng akin to waves produced when water is pushed, the team found. Similar effects occurred at marathons in Paris and Atlanta in 2017.

Marathon crowds are a special type in that everyone travels in the same direction. Eventually, this type of research could lead to new insight into other crowd formations, including those packed more tightly than marathon crowds, with pedestrians literally shoulder to shoulder. Such crowds sometimes result in deadly stampedes, such as the 2015 event at the hajj in Mecca, Saudi Arabia (SN: 4/7/07, p. 213). Better understanding of these crowd dynamics could help prevent similar tragedies.

Treating cystic fibrosis patients before birth could safeguard organs

A drug that treats a rare form of cystic fibrosis may have even better results if given before birth, a study in ferrets suggests.

The drug, known by the generic name ivacaftor, can restore the function of a faulty version of the CFTR protein, called CFTRG551D. The normal CFTR protein controls the flow of charged atoms in cells that make mucus, sweat, saliva, tears and digestive enzymes. People who are missing the CFTR gene and its protein, or have two copies of a damaged version of the gene, develop the lung disease cystic fibrosis, as well as diabetes, digestive problems and male infertility.
Ivacaftor can reduce lung problems in patients with the G551D protein defect, with treatment usually starting when a patient is a year old. But if the results of the new animal study carry over to humans, an even earlier start date could prove more effective in preventing damage to multiple organs.

Researchers used ferret embryos with two copies of the G551D version of the CFTR gene. Giving the drug to mothers while the ferrets were in the womb and then continuing treatment of the babies after birth prevented male infertility, pancreas problems and lung disease in the baby ferrets, called kits, researchers report March 27 in Science Translational Medicine. The drug has to be used continuously to prevent organ damage — when the drug was discontinued, the kits’ pancreases began to fail and lung disease set in.

Cystic fibrosis affects about 30,000 people in the United States and 70,000 worldwide. But only up to 5 percent of patients have the G551D defect.

Other researchers are testing combinations of three drugs, including ivacaftor, aimed at helping the roughly 90 percent of cystic fibrosis patients afflicted by another genetic mutation that causes the CFTR protein to lack an amino acid (SN: 11/24/18, p. 11). Those drug combos, if proven effective, might also work better if administered early, cystic fibrosis researcher Thomas Ferkol of Washington University School of Medicine in St. Louis writes in a commentary published with the study.

How scientists took the first picture of a black hole

Black holes are extremely camera shy. Supermassive black holes, ensconced in the centers of galaxies, make themselves visible by spewing bright jets of charged particles or by flinging away or ripping up nearby stars. Up close, these behemoths are surrounded by glowing accretion disks of infalling material. But because a black hole’s extreme gravity prevents light from escaping, the dark hearts of these cosmic heavy hitters remain entirely invisible.

Luckily, there’s a way to “see” a black hole without peering into the abyss itself. Telescopes can look instead for the silhouette of a black hole’s event horizon — the perimeter inside which nothing can be seen or escape — against its accretion disk. That’s what the Event Horizon Telescope, or EHT, did in April 2017, collecting data that has now yielded the first image of a supermassive black hole, the one inside the galaxy M87.

“There is nothing better than having an image,” says Harvard University astrophysicist Avi Loeb. Though scientists have collected plenty of indirect evidence for black holes over the last half century, “seeing is believing.”

Creating that first-ever portrait of a black hole was tricky, though. Black holes take up a minuscule sliver of sky and, from Earth, appear very faint. The project of imaging M87’s black hole required observatories across the globe working in tandem as one virtual Earth-sized radio dish with sharper vision than any single observatory could achieve on its own.
Putting the ‘solution’ in resolution
Weighing in around 6.5 billion times the mass of our sun, the supermassive black hole inside M87 is no small fry. But viewed from 55 million light-years away on Earth, the black hole is only about 42 microarcseconds across on the sky. That’s smaller than an orange on the moon would appear to someone on Earth. Still, besides the black hole at the center of our own galaxy, Sagittarius A* or Sgr A* — the EHT’s other imaging target — M87’s black hole is the largest black hole silhouette on the sky.
Only a telescope with unprecedented resolution could pick out something so tiny. (For comparison, the Hubble Space Telescope can distinguish objects only about as small as 50,000 microarcseconds.) A telescope’s resolution depends on its diameter: The bigger the dish, the clearer the view — and getting a crisp image of a supermassive black hole would require a planet-sized radio dish.
Even for radio astronomers, who are no strangers to building big dishes (SN Online: 9/29/17), “this seems a little too ambitious,” says Loeb, who was not involved in the black hole imaging project. “The trick is that you don’t cover the entire Earth with an observatory.”
Instead, a technique called very long baseline interferometry combines radio waves seen by many telescopes at once, so that the telescopes effectively work together like one giant dish. The diameter of that virtual dish is equal to the length of the longest distance, or baseline, between two telescopes in the network. For the EHT in 2017, that was the distance from the South Pole to Spain.

Telescopes, assemble!
The EHT was not always the hotshot array that it is today, though. In 2009, a network of just four observatories — in Arizona, California and Hawaii — got the first good look at the base of one of the plasma jets spewing from the center of M87’s black hole (SN: 11/3/12, p. 10). But the small telescope cohort didn’t yet have the magnifying power to reveal the black hole itself.

Over time, the EHT recruited new radio observatories. By 2017, there were eight observing stations in North America, Hawaii, Europe, South America and the South Pole. Among the newcomers was the Atacama Large Millimeter/submillimeter Array, or ALMA, located on a high plateau in northern Chile. With a combined dish area larger than an American football field, ALMA collects far more radio waves than other observatories.

“ALMA changed everything,” says Vincent Fish, an astronomer at MIT’s Haystack Observatory in Westford, Mass. “Anything that you were just barely struggling to detect before, you get really solid detections now.”
More than the sum of their parts
EHT observing campaigns are best run within about 10 days in late March or early April, when the weather at every observatory promises to be the most cooperative. Researchers’ biggest enemy is water in the atmosphere, like rain or snow, which can muddle with the millimeter-wavelength radio waves that the EHT’s telescopes are tuned to.

But planning for weather on several continents can be a logistical headache.

“Every morning, there’s a frenetic set of phone calls and analyses of weather data and telescope readiness, and then we make a go/no-go decision for the night’s observing,” says astronomer Geoffrey Bower of the Academia Sinica Institute of Astronomy and Astrophysics in Hilo, Hawaii. Early in the campaign, researches are picky about conditions. But toward the tail end of the run, they’ll take what they can get.

When the skies are clear enough to observe, researchers steer the telescopes at each EHT observatory toward the vicinity of a supermassive black hole and begin collecting radio waves. Since M87’s black hole and Sgr A* appear on the sky one at a time — each one about to rise just as the other sets — the EHT can switch back and forth between observing its two targets over the course of a single multi-day campaign. All eight observatories can track Sgr A*, but M87 is in the northern sky and beyond the South Pole station’s sight.

On their own, the data from each observing station look like nonsense. But taken together using the very long baseline interferometry technique, these data can reveal a black hole’s appearance.

Here’s how it works. Picture a pair of radio dishes aimed at a single target, in this case the ring-shaped silhouette of a black hole. The radio waves emanating from each bit of that ring must travel slightly different paths to reach each telescope. These radio waves can interfere with each other, sometimes reinforcing one another and sometimes canceling each other out. The interference pattern seen by each telescope depends on how the radio waves from different parts of the ring are interacting when they reach that telescope’s location.
For simple targets, such as individual stars, the radio wave patterns picked up by a single pair of telescopes provide enough information for researchers to work backward and figure out what distribution of light must have produced those data. But for a source with complex structure, like a black hole, there are too many possible solutions for what the image could be. Researchers need more data to work out how a black hole’s radio waves are interacting with each other, offering more clues about what the black hole looks like.

The ideal array has as many baselines of different lengths and orientations as possible. Telescope pairs that are farther apart can see finer details, because there’s a bigger difference between the pathways that radio waves take from the black hole to each telescope. The EHT includes telescope pairs with both north-south and east-west orientations, which change relative to the black hole as Earth rotates.

Pulling it all together
In order to braid together the observations from each observatory, researchers need to record times for their data with exquisite precision. For that, they use hydrogen maser atomic clocks, which lose about one second every 100 million years.

There are a lot of data to time stamp. “In our last experiment, we recorded data at a rate of 64 gigabits per second, which is about 1,000 times [faster than] your home internet connection,” Bower says.

These data are then transferred to MIT Haystack Observatory and the Max Planck Institute for Radio Astronomy in Bonn, Germany, for processing in a special kind of supercomputer called a correlator. But each telescope station amasses hundreds of terabytes of information during a single observing campaign — far too much to send over the internet. So the researchers use the next best option: snail mail. So far, there have been no major shipping mishaps, but Bower admits that mailing the disks is always a little nerve-wracking.

Though most of the EHT data reached Haystack and Max Planck within weeks of the 2017 observing campaign, there were no flights from South Pole until November. “We didn’t get the data back from the South Pole until mid-December,” says Fish, the MIT Haystack astronomer.

Filling in the blanks
Combining the EHT data still isn’t enough to render a vivid picture of a supermassive black hole. If M87’s black hole were a song, then imaging it using only the combined EHT data would be like listening to the piece played on a piano with a bunch of broken keys. The more working keys — or telescope baseline pairs — the easier it is to get the gist of the melody. “Even if you have some broken keys, if you’re playing all the rest of them correctly, you can figure out the tune, and that’s partly because we know what music sounds like,” Fish says. “The reason we can reconstruct images, even though we don’t have 100 percent of the information, is because we know what images look like” in general.
There are mathematical rules about how much randomness any given picture can contain, how bright it should be and how likely it is that neighboring pixels will look similar. Those basic guidelines can inform how software decides which potential images, or data interpretations, make the most sense.

Before the 2017 observing campaign, the EHT researchers held a series of imaging challenges to make sure their computer algorithms weren’t biased toward creating images to match expectations of what black holes should look like. One person would use a secret image to generate faux data of what telescopes would see if they were peering at that source. Then other researchers would try to reconstruct the original image.

“Sometimes the true image was not actually a black hole image,” Fish says, “so if your algorithm was trying to find a black hole shadow … you wouldn’t do well.” The practice runs helped the researchers refine the data processing techniques used to render the M87 image.

Black holes and beyond
So, the black hole inside M87 finally got its closeup. Now what?

The EHT’s black hole observations are expected to help answer questions like how some supermassive black holes, including M87’s, launch such bright plasma jets (SN Online: 3/29/19). Understanding how gas falls into and feeds black holes could also help solve the mystery of how some black holes grew so quickly in the early universe, Loeb says (SN Online: 3/16/18).

The EHT could also be used, Loeb suggests, to find pairs of supermassive black holes orbiting one another — similar to the two stellar mass black holes whose collision created gravitational waves detected in 2015 by the Advanced Laser Interferometer Gravitational-Wave Observatory, or Advanced LIGO (SN: 3/5/16, p. 6). Getting a census of these binaries may help researchers identify targets for the Laser Interferometer Space Antenna, or LISA, which will search from space for gravitational waves kicked up by the movement of objects like black holes (SN Online: 6/20/17).
The EHT doesn’t have many viable targets other than supermassive black holes, says astrophysicist Daniel Marrone, at the University of Arizona in Tucson. There are few other things in the universe that appear as tiny but luminous as the space surrounding a supermassive black hole. “You have to be able to get enough light out of the really tiny patches of sky that we can detect,” Marrone says. “In principle, we could be reading alien license plates or something,” but they’d need to be super bright.

Too bad for alien seekers. Still, even if the EHT is a one-trick pony, spying supermassive black holes is a pretty neat trick.

Here’s how polar bears might get traction on snow

Tiny “fingers” can help polar bears get a grip.

Like the rubbery nubs on the bottom of baby socks, microstructures on the bears’ paw pads offer some extra friction, scientists report November 1 in the Journal of the Royal Society Interface. The pad protrusions may keep polar bears from slipping on snow, says Ali Dhinojwala, a polymer scientist at the University of Akron in Ohio who has also studied the sticking power of gecko feet (SN: 8/9/05).
Nathaniel Orndorf, a materials scientist at Akron who focuses on ice, adhesion and friction, was interested in the work Dhinojwala’s lab did on geckos, but “we can’t really put geckos on the ice,” he says. So he turned to polar bears.

Orndorf teamed up with Dhinojwala and Austin Garner, an animal biologist now at Syracuse University in New York, and compared the paws of polar bears, brown bears, American black bears and a sun bear. All but the sun bear had paw pad bumps. But the polar bears’ bumps looked a little different. For a given diameter, their bumps tend to be taller, the team found. That extra height translates to more traction on lab-made snow, experiments with 3-D printed models of the bumps suggest.

Until now, scientists didn’t know that bump shape could make the difference between gripping and slipping, Dhinojwala says.
Polar bear paw pads are also ringed with fur and are smaller than those of other bears, the team reports, adaptations that might let the Arctic animals conserve body heat as they trod upon ice. Smaller pads generally mean less real estate for grabbing the ground. So extra-grippy pads could help polar bears make the most of what they’ve got, Orndorf says.

Along with bumpy pads, the team hopes to study polar bears’ fuzzy paws and short claws, which might also give the animals a nonslip grip.

Common, cheap ingredients can break down some ‘forever chemicals’

There’s a new way to rip apart harmful “forever chemicals,” scientists say.

Perfluoroalkyl and polyfluoroalkyl substances, also known as PFAS, are found in nonstick pans, water-repellent fabrics and food packaging and they are pervasive throughout the environment. They’re nicknamed forever chemicals for their ability to stick around and not break down. In part, that’s because PFAS have a super strong bond between their carbon and fluorine atoms (SN: 6/4/19). Now, using a bit of heat and two relatively common compounds, researchers have degraded one major type of forever chemical in the lab, the team reports in the Aug. 19 Science. The work could help pave the way for a process for breaking down certain forever chemicals commercially, for instance by treating wastewater.
“The fundamental knowledge of how the materials degrade is the single most important thing coming out of this study,” organic chemist William Dichtel said in an August 16 news conference.

While some scientists have found relatively simple ways of breaking down select PFAS, most degradation methods require harsh, energy-intensive processes using intense pressure — in some cases over 22 megapascals — or extremely high temperatures — sometimes upwards of 1000⁰ Celsius — to break the chemical bonds (SN: 6/3/22).

Dichtel, of Northwestern University in Evanston, Ill., and his team experimented with two substances found in nearly every chemistry lab cabinet: sodium hydroxide, also known as lye, and a solvent called dimethyl sulfoxide, or DMSO. The team worked specifically with a group of forever chemicals called PFCAs, which contain carboxylic acid and constitute a large percentage of all PFAS. Some of these kinds of forever chemicals are found in water-resistant clothes.

When the team combined PFCAs with the lye and DMSO at 120⁰ C and with no extra pressure needed, the carboxylic acid fell off the chemical and became carbon dioxide in a process called decarboxylation. What happened next was unexpected, Dichtel said. Loss of the acid led to a process causing “the entire molecule to fall apart in a cascade of complex reactions.” This cascade involved steps that degraded the rest of the chemical into fluoride ions and smaller carbon-containing products, leaving behind virtually no harmful by-products. .

“It’s a neat method, it’s different from other ones that have been tried,” says Chris Sales, an environmental engineer at Drexel University in Philadelphia who was not involved in the study. “The biggest question is, how could this be adapted and scaled up?” Northwestern has filed a provisional patent on behalf of the researchers.

Understanding this mechanism is just one step in undoing forever chemicals, Dichtel’s team said. And more research is needed: There are other classes of PFAS that require their own solutions. This process wouldn’t work to tackle PFAS out in the environment, because it requires a concentrated amount of the chemicals. But it could one day be used in wastewater treatment plants, where the pollutants could be filtered out of the water, concentrated and then broken down.

Why mosquitoes are especially good at smelling you

Some mosquitoes have a near-foolproof thirst for human blood. Previous attempts to prevent the insects from tracking people down by blocking part of mosquitoes’ ability to smell have failed. A new study hints it’s because the bloodsuckers have built-in workarounds to ensure they can always smell us.

For most animals, individual nerve cells in the olfactory system can detect just one type of odor. But Aedes aegypti mosquitoes’ nerve cells can each detect many smells, researchers report August 18 in Cell. That means if a cell were to lose the ability to detect one human odor, it still can pick up on other scents.
The study provides the most detailed map yet of a mosquito’s sense of smell and suggests that concealing human aromas from the insects could be more complicated than researchers thought.

Repellents that block mosquitoes from detecting human-associated scents could be especially tricky to make. “Maybe instead of trying to mask them from finding us, it would be better to find odorants that mosquitoes don’t like to smell,” says Anandasankar Ray, a neuroscientist at the University of California, Riverside who was not involved in the work. Such repellents may confuse or irritate the bloodsuckers and send them flying away (SN: 9/21/11; SN: 3/4/21).

Effective repellents are a key tool to prevent mosquitoes from transmitting disease-causing viruses such as dengue and Zika (SN: 7/11/22). “Mosquitoes are responsible for more human deaths than any other creature,” says Olivia Goldman, a neurobiologist at Rockefeller University in New York City. “The better we understand them, the better that we can have these interventions.”

Mosquitoes that feed on people home in on a variety of cues when hunting, including body heat and body odor. The insects smell using their antennae and small appendages close to the mouth. Using three types of sensors in olfactory nerve cells, they can detect chemicals such as carbon dioxide from exhaled breath or components of body odor (SN: 7/16/15).

In previous work, researchers thought that blocking some sensors might hide human scents from mosquitoes by disrupting the smell messages sent to the brain (SN: 12/5/13). But even those sensor-deprived mosquitoes can still smell and bite people, says neurobiologist Margo Herre also of Rockefeller University.

So Goldman, Herre and colleagues added fluorescent labels to A. aegypti nerve cells, or neurons, to learn new details about how the mosquito brain deciphers human odors. Surprisingly, rather than finding the typical single type of sensor per nerve cell, the team found that individual mosquito neurons appear more like sensory hubs.

Genetic analyses confirmed that some of the olfactory nerve cells had more than one type of sensor. Some cells produced electrical signals in response to several mosquito-attracting chemicals found in humans such as octenol and triethyl amine — a sign the neurons could detect more than one type of odor molecule. A separate study published in April in eLife found similar results in fruit flies, which suggests such a system may be common among insects.

It’s unclear why having redundant ways of detecting people’s odors might be useful to mosquitoes. “Different people can smell very different from one another,” says study coauthor Meg Younger, a neurobiologist at Boston University. “Maybe this is a setup to find a human regardless of what variety of human body odor that human is emitting.”

Oort cloud comets may spin themselves to death

Comets from the solar system’s deep freezer often don’t survive their first encounter with the sun. Now one scientist thinks he knows why: Solar warmth makes some of the cosmic snowballs spin so fast, they fall apart.

This suggestion could help solve a decades-old mystery about what destroys many “long-period” comets, astronomer David Jewitt reports in a study submitted August 8 to arXiv.org. Long-period comets originate in the Oort cloud, a sphere of icy objects at the solar system’s fringe (SN: 8/18/08). Those that survive their first trip around the sun tend to swing by our star only once every 200 years.
“These things are stable out there in the Oort cloud where nothing ever happens. When they come toward the sun, they heat up, all hell breaks loose, and they fall apart,” Jewitt says.

The Dutch astronomer Jan Oort first proposed the Oort cloud as a cometary reservoir in 1950. He realized that many of its comets that came near Earth were first-time visitors, not return travelers. Something was taking the comets out, but no one knew what.

One possibility was that the comets die by sublimating all of their water away as they near the heat of the sun until there’s nothing left. But that didn’t fit with observations of comets that seemed to physically break up into smaller pieces. The trouble was, those breakups are hard to watch in real time.

“The disintegrations are really hard to observe because they’re unpredictable, and they happen quickly,” Jewitt says.

He ran into that difficulty when he tried to observe Comet Leonard, a bright comet that put on a spectacular show in winter 2021–2022. Jewitt had applied for time to observe the comet with the Hubble Space Telescope in April and June 2022. But by February, the comet had already disintegrated. “That was a wake-up call,” Jewitt says.

So Jewitt turned to historical observations of long-period comets that came close to the sun since the year 2000. He selected those whose water vapor production had been indirectly measured via an instrument called SWAN on NASA’s SOHO spacecraft, to see how quickly the comets were losing mass. He also picked out comets whose movements deviating from their orbits around the sun had been measured. Those motions are a result of water vapor jets pushing the comet around, like a spraying hose flopping around a garden.

That left him with 27 comets, seven of which did not survive their closest approach to the sun.

Jewitt expected that the most active comets would disintegrate the fastest, by puffing away all their water. But he found the opposite: It turns out that the least active comets with the smallest dirty snowball cores were the most at risk of falling apart.

“Basically, being a small nucleus near the sun causes you to die,” Jewitt says. “The question is, why?”

It wasn’t that the comets were torn apart by the sun’s gravity — they didn’t get close enough for that. And simply sublimating until they went poof would have been too slow a death to match the observations. The comets are also unlikely to collide with anything else in the vastness of space and break apart that way. And a previous suggestion that pressure builds up inside the comets until they explode like a hand grenade doesn’t make sense to Jewitt. Comets’ upper few centimeters of material would absorb most of the sun’s heat, he says, so it would be difficult to heat the center of the comet enough for that to work.

The best remaining explanation, Jewitt says, is rotational breakup. As the comet nears the sun and its water heats up enough to sublimate, jets of water vapor form and make the core start to spin like a catherine wheel firework. Smaller cores are easier to push around than a larger one, so they spin more easily.

“It just spins faster and faster, until it doesn’t have enough tensile strength to hold together,” Jewitt says. “I’m pretty sure that’s what’s happening.”

That deadly spin speed is actually quite slow. Spinning at about half a meter per second could spell curtains for a kilometer-sized comet, he calculates. “You can walk faster.”

But comets are fragile. If you held a fist-sized comet in front of your face, a sneeze would destroy it, says planetary astronomer Nalin Samarasinha of the Planetary Science Institute in Tucson, who was not involved in the study.

Samarasinha thinks Jewitt’s proposal is convincing. “Even though the sample size is small, I think it is something really happening.” But other things might be destroying these comets too, he says, and Jewitt agrees.

Samarasinha is holding out for more comet observations, which could come when the Vera Rubin Observatory begins surveying the sky in 2023. Jewitt’s idea “is something which can be observationally tested in a decade or two.”